1H-Benzimidazole-6-carboximidamide, 2-(2-(5-(aminoiminomethyl)-2-benzofuranyl)ethenyl)- | 907169-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1H-Benzimidazole-6-carboximidamide, 2-(2-(5-(aminoiminomethyl)-2-benzofuranyl)ethenyl)-
• 英文别名: 2-[(E)-2-(5-carbamimidoyl-1-benzofuran-2-yl)ethenyl]-3H-benzimidazole-5-carboximidamide
• CAS: 907169-69-1
• 化学式: C₁₉H₁₆N₆O
• 分子量: 344.4
• InChiKey: OOKWWPFCCCMWIS-ZZXKWVIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• METHODS OF INHIBITING VIRAL INFECTION
  申请人：Functional Genetics, Inc.

  公开号：EP2207801A1

  公开（公告）日：2010-07-21
• Antiviral Compounds and Methods of Using Thereof
  申请人：Aman Mohammad Javad

  公开号：US20090012107A1

  公开（公告）日：2009-01-08

  Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods of preventing, inhibiting, or reducing the viral activity of various viruses are provided as well as methods of treating viral infections.
• METHOHDS OF INHIBITING VIRAL INFECTION
  申请人：Kinch Michael

  公开号：US20090170890A1

  公开（公告）日：2009-07-02

  A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI-103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg-200 mg/kg of body weight.
• NOVEL THERAPEUTICS FOR BRAIN CANCER
  申请人：The Regents of the University of California

  公开号：US20170182049A1

  公开（公告）日：2017-06-29

  Provided herein are novel compositions and methods to inhibit Olig2 activity. The Olig2 inhibitors and methods of using the same are useful, inter alia, for treating cancer. In particular the Olig2 inhibitors may be used to treat glioblastoma. Further, provided are peptide compositions capable of inhibiting Olig 2.
• US7999001B2
  申请人：——

  公开号：US7999001B2

  公开（公告）日：2011-08-16