3-<4-Carboxy-phenoxy>-propionsaeure | 35005-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-<4-Carboxy-phenoxy>-propionsaeure
• 英文别名: β-(4-Carboxy-phenoxy)-propionsaeure；3-(4-Carboxy-phenoxy)-propionsaeure；4-(2-Carboxyethoxy)benzoic acid
• CAS: 35005-19-7
• 化学式: C₁₀H₁₀O₅
• 分子量: 210.186
• InChiKey: GSIWQGAOMQHQJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-<4-Carboxy-phenoxy>-propionsaeure 在 ice 、 resultant precipitate 作用下， 以 硫酸 为溶剂， 反应 4.0h， 以to give the title compound (1.6 g)的产率得到4-氧代苯并二氢吡喃-6-羧酸
  参考文献：
  名称：

  Substituted isoquinoline derivatives and their use as anticonvulsants

  摘要：

  本发明涉及取代异喹啉衍生物及其作为抗癫痫药物的用途。

  公开号：

  US20030144320A1
• 作为产物：
  描述：

  4-甲基苯氧基丙腈 在 盐酸 、 potassium permanganate 、 溶剂黄146 作用下， 生成 3-<4-Carboxy-phenoxy>-propionsaeure
  参考文献：
  名称：

  Darmanaden, R.; Dhanutirto, H.; Castel, J., Farmaco, Edizione Scientifica, 1984, vol. 39, # 10, p. 876 - 887

  摘要：

  DOI：

文献信息

• Substituted isoquinoline derivatives and their use as anticonvulsants
  申请人：SmithKline Beecham p.l.c.

  公开号：US20010016657A1

  公开（公告）日：2001-08-23

  This invention relates to substituted isoquinoline derivatives and their use as anticonvulsants.

  本发明涉及取代异喹啉衍生物及其作为抗癫痫药物的用途。
• Impact resistant polymeric compositions
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0211467A2

  公开（公告）日：1987-02-25

  Impact resistant polymeric composition comprising a polyamide or a polyester and a thermally stable modified selectively hydrogenated high 1,2-content block copolymer wherein at least one acid compound is grafted to the block copolymer at a secondary or tertiary carbon position.

  抗冲击聚合物组合物，包括聚酰胺或聚酯和热稳定改性选择性氢化高 1,2 含量嵌段共聚物，其中至少有一种酸化合物在二级或三级碳位置接枝到嵌段共聚物上。
• Novel polyanhydrides
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0343889A2

  公开（公告）日：1989-11-29

  There are provided novel homopolyanhdyrides of carboxyaryloxyalkanoic acids, e.g. p-carboxyphenoxyacetic acid or 6-(p-carboxyphenoxy)hexanoic acid, capable of being formed into shaped articles. The homopolyanhydrides may be prepared by heating under reflux a solution of the acid monomer in acetic anhydride to form a mixed anhydride of the acid monomer and acetic acid and melt polycondensing the prepolymer by heating it under vacuum in an inert atmosphere. Due to their property of hydrolytic cleavage at predictable rates, the homopolyanhydrides are suitable as polymer matrices providing for the controlled release of an agent such as a drug.

  本发明提供了新型的羧基芳氧基烷酸均聚氰基酸酐，例如对羧基苯氧基乙酸或 6-(对羧基苯氧基)己酸，可制成成型物品。均聚酸酐的制备方法是：在回流条件下加热酸单体在乙酸酐中的溶液，形成酸单体和乙酸的混合酸酐，然后在惰性气氛中真空加热预聚物，使其熔融缩聚。由于均聚酸酐具有以可预测的速度水解裂解的特性，因此适合用作聚合物基质，用于控制药物等制剂的释放。
• Thermoplastic resin composition
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0439138A2

  公开（公告）日：1991-07-31

  Thermoplastic resin composition comprising the following components A and B is presented which improves the compatibility of component resins, to achieve a thermoplastic resin having excellent molding property and mechanical strength: A. 90 to 10 wt% of a polyolefin resin containing a substituted silyl group represented by general formula; -SiRnY₃-n (wherein, R is aliphatic hydrocarbon group; Y is hydrolyzable group or hydroxyl group; n represents 0, 1 or 2), and B. 10 to 90 wt% of saturated polyester resin or hydroxyalkylated polycarbonate resin or hydroxyalkylated polyphenylene ether resin.

  本发明介绍了由以下组分 A 和 B 组成的热塑性树脂组合物，它能改善各组分树脂的相容性，使热塑性树脂具有优异的成型性能和机械强度： A.90 至 10 wt%的聚烯烃树脂，其中含有由通式表示的取代硅基； -SiRnY₃-n (其中，R 为脂肪族烃基；Y 为可水解基团或羟基；n 代表 0、1 或 2），以及 B.10 至 90 wt%的饱和聚酯树脂或羟烷基化聚碳酸酯树脂或羟烷基化聚苯醚树脂。
• Thermoplastic polyphenylene ether resin composition
  申请人：MITSUBISHI PETROCHEMICAL CO., LTD.

  公开号：EP0467261A2

  公开（公告）日：1992-01-22

  A thermoplastic resin composition comprising (A) from about 10 to about 90% by weight of a hydroxyalkylated polyphenylene ether represented by formula (I): wherein A represents a residue of a polyphenylene ether from which a hydroxyl group is removed; and n represents an integer of from 1 to 10, and (B) from about 10 to about 90% by weight of a resin selected from a carboxyl-containing olefin resin, an epoxy-containing olefin resin, a hydroxyl-containing olefin resin, a polyamide resin, and a saturated polyester resin, provided that when (B) is the olefin resin, the hydroxyalkylated polyphenylene ether also can be represented by formula (II): werein A is defined as above; X represents an oxygen atom or a nitrogen atom; R1 represents an alkylene group having from 1 to 12 carbon atoms; R2 and R3 each represents a hydrocarbon group having from 1 to 6 carbon atoms; s represents 1 when X is an oxygen atom, or 2 when X is a nitrogen atom; and t represents an integer of from 1 to 3.

  一种热塑性树脂组合物，包含 (A) 按重量计约 10%至约 90%的由式 (I) 代表的羟基烷基化聚苯醚： 其中 A 代表去除了羟基的聚苯醚残留物；n 代表 1 至 10 的整数、 和(B)约 10%至约 90%（按重量计）的选自含羧基烯烃树脂、含环氧基烯烃树脂、含羟基烯烃树脂、聚酰胺树脂和饱和聚酯树脂的树脂，条件是当(B)为烯烃树脂时，羟基烷基化聚苯醚也可以由式(II)表示： 式中 A 的定义同上；X 代表氧原子或氮原子；R1 代表具有 1 至 12 个碳原子的亚烷基；R2 和 R3 分别代表具有 1 至 6 个碳原子的烃基；当 X 为氧原子时，s 代表 1；当 X 为氮原子时，s 代表 2；t 代表 1 至 3 的整数。