1-(4-benzyloxycarbonylamino-3,5-dimethylphenyl)-1-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)cyclohexane | 331984-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-benzyloxycarbonylamino-3,5-dimethylphenyl)-1-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)cyclohexane
• CAS: 331984-77-1
• 化学式: C₃₅H₄₄N₂O₄
• 分子量: 556.745
• InChiKey: AQOIFSNGTQEELN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-(4-benzyloxycarbonylamino-3,5-dimethylphenyl)-1-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)cyclohexane 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以74%的产率得到1-(4-benzyloxycarbonylamino-3,5-dimethylphenyl)-1-(4-amino-3,5-dimethylphenyl)cyclohexane
  参考文献：
  名称：

  A Building Block Method for the Synthesis of Higher Cycloamides

  摘要：

  Series of cyclic amides containing optically active helicene, (P)-1, 12-dimethylbenzo[c]phenanthrene, are synthesized using a building block method. The building block consists of one (P)-helicene unit and one dianiline unit with its amino-terminal-protected with benzyloxycarbonyl and its acid terminal activated as acid chloride. The coupling with (P,P....)-[(n - 3) + (n - 2)]diamine followed by deprotection gives (P,P....)-[(n - 1) + n]diamine, which possesses n - 1 parts of (P)-helicene and n parts of dianiline. Cyclization of the (PP....)-[(n - 1) + n]diamine with helicenediacid dichloride gives (P,P....)-[n + n]cycloamide. All the members of (P,P)-[2 + 2]cycloamide to (P,P,P,P,P,P,P,P,P,P)-[10 + 10]cycloamide are synthesized using this method, and are compared spectroscopically.

  DOI：

  10.1021/jo0013047
• 作为产物：
  描述：

  氯甲酸苄酯 、 1-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)-1-(4-amino-3,5-dimethylphenyl)cyclohexane 在 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以90%的产率得到1-(4-benzyloxycarbonylamino-3,5-dimethylphenyl)-1-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)cyclohexane
  参考文献：
  名称：

  A Building Block Method for the Synthesis of Higher Cycloamides

  摘要：

  Series of cyclic amides containing optically active helicene, (P)-1, 12-dimethylbenzo[c]phenanthrene, are synthesized using a building block method. The building block consists of one (P)-helicene unit and one dianiline unit with its amino-terminal-protected with benzyloxycarbonyl and its acid terminal activated as acid chloride. The coupling with (P,P....)-[(n - 3) + (n - 2)]diamine followed by deprotection gives (P,P....)-[(n - 1) + n]diamine, which possesses n - 1 parts of (P)-helicene and n parts of dianiline. Cyclization of the (PP....)-[(n - 1) + n]diamine with helicenediacid dichloride gives (P,P....)-[n + n]cycloamide. All the members of (P,P)-[2 + 2]cycloamide to (P,P,P,P,P,P,P,P,P,P)-[10 + 10]cycloamide are synthesized using this method, and are compared spectroscopically.

  DOI：

  10.1021/jo0013047