3-methyl-2-methylene-1-phenyl-3-butenol | 72014-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-2-methylene-1-phenyl-3-butenol
• 英文别名: 3-Methyl-2-methylidene-1-phenylbut-3-en-1-ol
• CAS: 72014-10-9
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: OYZAOJYVWOPBCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-Methyl-butadien-(2.3)-yl-magnesium-bromid 、 苯甲醛 生成 3-methyl-2-methylene-1-phenyl-3-butenol
  参考文献：
  名称：

  Organometalliques (M = Mg, Zn, Al) derivant de bromures α-alleniques

  摘要：

  DOI：

  10.1016/s0022-328x(00)96158-8

文献信息

• Synthesis of pinacol esters of 2,3-alkadienylboronic acid via the copper(I) mediated coupling reaction of Knochel's (dialkoxyboryl)methylzinc reagents with propargylic tosylates
  作者：Ilya Gridnev、Gen Kanai、Norio Miyaura、Akira Suzuki

  DOI：10.1016/0022-328x(94)85018-6

  日期：1994.11

  The reaction of propargyl tosylates (1) with (dialkoxyboryl)methyl-copper(I) reagents, prepared in situ from Knochel's (dialkoxyboryl)-methylzinc iodide (2) and CuCN · 2LiCl, produced 2,3-alkadienyl-boronates (3) in moderate yields. The reaction proceeded regioselectively to provide an SN2' substitution product without contamination by other products such as 3-alkynylboronate.

  炔丙基甲苯磺酸酯（1）与由（Knochel's（dialkoxyboryl）-methylziodide（2）和CuCN·2LiCl原位制备的（dialkoxyboryl ）methyl-copper（I）试剂反应生成2,3-alkadienyl-boronates（3）产量中等。反应区域选择性地进行，以提供一个S N 2'取代产物，而不受其他产物如3-炔基硼酸酯的污染。
• Expanded Scope in Ethylene−Alkyne Cross-Metathesis:  Coordinating Heteroatom Functionality at the Propargylic Position
  作者：Jason A. Smulik、Steven T. Diver

  DOI：10.1021/ol006035l

  日期：2000.7.1

  [GRAPHICS]The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene-alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions, Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.