2-[[6-(3,4-Difluorophenoxy)-1-(2-ethoxyethyl)benzimidazol-2-yl]methylamino]-2-methylpropanamide | 1233230-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[[6-(3,4-Difluorophenoxy)-1-(2-ethoxyethyl)benzimidazol-2-yl]methylamino]-2-methylpropanamide
• CAS: 1233230-20-0
• 化学式: C₂₂H₂₆F₂N₄O₃
• 分子量: 432.47
• InChiKey: NSXSNAWRGUFNBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• NOVEL BICYCLIC HETEROCYCLIC COMPOUND
  申请人：Tsubio Katsunori

  公开号：US20110294804A1

  公开（公告）日：2011-12-01

  The invention provides a compound for the treatment or prophylaxis of pathology involving SNS, specifically diseases such as neuropathic pain, nociceptive pain, dysuria, multiple sclerosis and the like. The compound is represented by formula (1) or a pharmaceutically acceptable salt thereof wherein R 1 is a hydrogen atom or the like, L is a single bond, —O— or the like, R 2 is a phenyl group or the like, X is a carbon atom or a nitrogen atom, and R 3 , R 4 , R 5a , R 5b , R 6 and R 7 are each independently a substituted or unsubstituted alkyl group or the like:
• US8471038B2
  申请人：——

  公开号：US8471038B2

  公开（公告）日：2013-06-25