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4-{1H-pyrrolo[2,3-c]pyridin-3-yl}morpholine | 1427555-91-6

中文名称
——
中文别名
——
英文名称
4-{1H-pyrrolo[2,3-c]pyridin-3-yl}morpholine
英文别名
4-(1H-pyrrolo[2,3-c]pyridin-3-yl)morpholine
4-{1H-pyrrolo[2,3-c]pyridin-3-yl}morpholine化学式
CAS
1427555-91-6
化学式
C11H13N3O
mdl
——
分子量
203.244
InChiKey
CMQDNNNGRVQALX-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.7
  • 重原子数:
    15
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.36
  • 拓扑面积:
    41.2
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    4-碘甲苯4-{1H-pyrrolo[2,3-c]pyridin-3-yl}morpholinepotassium phosphatecopper(l) iodideN,N'-二甲基乙二胺 作用下, 以 N,N-二甲基甲酰胺 为溶剂, 反应 1.0h, 以2%的产率得到4-[1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]morpholine
    参考文献:
    名称:
    NEW ENZYME INHIBITOR COMPOUNDS
    摘要:
    2-{4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}乙基-1-胺; 3-氨基丙基 4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酸酯; 1-{4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}-4-(二甲基氨基)丁酮; 5-氨基-1-{4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}戊酮; N-(2-氨基乙基)-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; N-(3-氨基丙基)-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; 4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]-N-[3-(二甲胺基)丙基]哌啶-1-羧酰胺; 1-({4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)哌嗪; 4-({4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)吗啉; 1-({4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)-1,4-二氮杂环庚烷; 乙酸乙酯 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 乙酸乙酯 1-[1-(4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸; N-(2-氨基乙基)-1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酰胺; 4-({1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-基}羰基)吗啉; 1-({1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-基}羰基)哌嗪; {4-[1-(4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基}甲醇; {4-[1-(4-甲基-苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-2-基}甲醇; [(3R)-4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基]甲醇; 甲酸甲酯 4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酸酯; N-(2-氨基乙基)-4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酰胺; 2-{4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基}乙基-1-醇; 甲酸甲酯 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-羧酸酯; N-(2-氨基乙基)-1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-羧酰胺; 1-({1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-基}羰基)哌嗪; 4-[1-(4-甲基苯基)-1H-吡咯并[2,3-c]吡啶-3-基]吗啉; 1-(4-氯苯基)-3-(哌啶-4-基)-1H-吡咯并[2,3-c]吡啶-4-醇; N-丁基-1-(4-氯苯基)-N-甲基-1H-吡唑并[3,4-c]吡啶-3-胺; 1-[4-(氟甲基)苯基]-3-(氧杂环丁基)-1H-吡唑并[3,4-c]吡啶; 和3-({4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-1-基}甲基)吡啶可用于抑制SSAO活性。
    公开号:
    US20140357623A1
  • 作为产物:
    描述:
    3-硝基吡啶N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 偶氮二异丁腈 、 palladium 10% on activated carbon 、 potassium tert-butylate氢气 作用下, 以 四氢呋喃甲醇四氯化碳乙酸乙酯乙腈 为溶剂, -78.0~55.0 ℃ 、100.0 kPa 条件下, 反应 7.0h, 生成 4-{1H-pyrrolo[2,3-c]pyridin-3-yl}morpholine
    参考文献:
    名称:
    [EN] NEW ENZYME INHIBITOR COMPOUNDS
    [FR] NOUVEAUX COMPOSÉS INHIBITEURS ENZYMATIQUES
    摘要:
    2- {4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}乙基-1-胺; 3-氨基丙基4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酸酯; 1- {4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}-4- (二甲基氨基)丁酮; 5-氨基-1- {4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3- 基]哌啶-1-基}戊酮; N- (2-氨基乙基)-4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; N- (3-氨基丙基)-4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; 4- [1- (4-氯苯基)-1H-吡咯并[2,3- c]吡啶-3-基]-N- [3- (二甲基氨基)丙基]哌啶-1-羧酰胺; 1- ({4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)哌嗪; 4- ({4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)吗啉; 1- ({4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)-1,4-二氮杂辛烷; 乙基1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 乙基1- [1- (4- 甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 1- [1- (4- 氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸; N- (2-氨基乙基)-1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酰胺; 4- ({1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4- 基}羰基)吗啉; 1- ({1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶- 4-基}羰基)哌嗪; {4- [1- (4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉- 3-基}甲醇; {4- [1- (4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-2-基}甲醇; [(3R)-4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3- 基]甲醇; 甲基4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酸酯; N- (2-氨基乙基)-4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]吗啉-3-羧酰胺; 2- {4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]吗啉-3-基}乙基-1-醇; 甲基1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]哌啶-2-羧酸酯; N- (2-氨基乙基)-1- [1- (4-氯苯基)-1H-吡唑并[3,4- c]吡啶-3-基]哌啶-2-羧酰胺; 1- ({1- [1- (4-氯苯基)-1H-吡唑并[3,4- c]吡啶-3-基]哌啶-2-基}羰基)哌嗪; 4- [1- (4-甲基苯基)-1H-吡咯并[2,3- c]吡啶-3-基]吗啉; 1- (4-氯苯基)-3- (哌啶-4-基)-1H-吡咯并[2,3-c]吡啶-4- 醇; N-丁基-1- (4-氯苯基)-N-甲基-1H-吡唑并[3,4-c]吡啶-3-胺; 1- [4- (氟甲基)苯基]-3- (氧杂环丁基)-1H-吡咯并[3,4-c]吡啶; 和3- ({4- [1- (4- 氯苯基)-1H-吡咯并[3,4-c]吡啶-3-基]哌啶-1-基}甲基)吡啶对于抑制SSAO活性是有用的。
    公开号:
    WO2013037411A1
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文献信息

  • [EN] NEW ENZYME INHIBITOR COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS INHIBITEURS ENZYMATIQUES
    申请人:PROXIMAGEN LTD
    公开号:WO2013037411A1
    公开(公告)日:2013-03-21
    2-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}ethan-1-amine; 3- aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate; 1-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}-4- (dimethylamino)butan-1-one; 5-amino-1-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3- yl]piperidin-1-yl}pentan-1-one; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3- c]pyridin-3-yl]piperidine-1-carboxamide; N-(3-aminopropyl)-4-[1-(4-chlorophenyl)-1H- pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3- c]pyridin-3-yl]-N-[3-(dimethylamino)propyl]piperidine-1-carboxamide; 1-(4-[1-(4- chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)piperazine; 4-(4-[1-(4- chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine; 1-(4-[1-(4- chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-1,4-diazepane; ethyl 1- [1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; ethyl 1-[1-(4- methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; 1-[1-(4- chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylic acid; N-(2- aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxamide; 4-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4 yl}carbonyl)morpholine; 1-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin- 4-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin- 3-yl}methanol; 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methanol; [(3R)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3- yl]methanol; methyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3- carboxylate; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3- yl]morpholine-3-carboxamide; 2-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3- yl]morpholin-3-yl}ethan-1-ol; methyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3- yl]piperidine-2-carboxylate; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4- c]pyridin-3-yl]piperidine-2-carboxamide; 1-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4- c]pyridin-3-yl]piperidin-2-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrrolo[2,3- c]pyridin-3-yl]morpholine; 1-(4-chlorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-4- ol; N-butyl-1-(4-chlorophenyl)-N-methyl-1H-pyrazolo[3,4-c]pyridin-3-amine; 1-[4- (fluoromethyl)phenyl]-3-(oxan-4-yl)-1H-pyrazolo[3,4-c]pyridine; and 3-(4-[1-(4- chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-1-yl}methyl)pyridine are useful for the inhibition of SSAO activity.
    2- 4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}乙基-1-胺; 3-氨基丙基4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酸酯; 1- 4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}-4- (二甲基氨基)丁酮; 5-氨基-1- 4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3- 基]哌啶-1-基}戊酮; N- (2-氨基乙基)-4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; N- (3-氨基丙基)-4- [1- (4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; 4- [1- (4-氯苯基)-1H-吡咯并[2,3- c]吡啶-3-基]-N- [3- (二甲基氨基)丙基]哌啶-1-羧酰胺; 1- (4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)哌嗪; 4- (4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)吗啉; 1- (4- [1- (4- 氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)-1,4-二氮杂辛烷; 乙基1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 乙基1- [1- (4- 甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 1- [1- (4- 氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸; N- (2-氨基乙基)-1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酰胺; 4- (1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4- 基}羰基)吗啉; 1- (1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶- 4-基}羰基)哌嗪; 4- [1- (4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉- 3-基}甲醇; 4- [1- (4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-2-基}甲醇; [(3R)-4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3- 基]甲醇; 甲基4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酸酯; N- (2-氨基乙基)-4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]吗啉-3-羧酰胺; 2- 4- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]吗啉-3-基}乙基-1-醇; 甲基1- [1- (4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3- 基]哌啶-2-羧酸酯; N- (2-氨基乙基)-1- [1- (4-氯苯基)-1H-吡唑并[3,4- c]吡啶-3-基]哌啶-2-羧酰胺; 1- (1- [1- (4-氯苯基)-1H-吡唑并[3,4- c]吡啶-3-基]哌啶-2-基}羰基)哌嗪; 4- [1- (4-甲基苯基)-1H-吡咯并[2,3- c]吡啶-3-基]吗啉; 1- (4-氯苯基)-3- (哌啶-4-基)-1H-吡咯并[2,3-c]吡啶-4- 醇; N-丁基-1- (4-氯苯基)-N-甲基-1H-吡唑并[3,4-c]吡啶-3-胺; 1- [4- (氟甲基)苯基]-3- (氧杂环丁基)-1H-吡咯并[3,4-c]吡啶; 和3- (4- [1- (4- 氯苯基)-1H-吡咯并[3,4-c]吡啶-3-基]哌啶-1-基}甲基)吡啶对于抑制SSAO活性是有用的。
  • US9150574B2
    申请人:——
    公开号:US9150574B2
    公开(公告)日:2015-10-06
  • NEW ENZYME INHIBITOR COMPOUNDS
    申请人:Evans David
    公开号:US20140357623A1
    公开(公告)日:2014-12-04
    2-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}ethan-1-amine; 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate; 1-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}-4-(dimethylamino)butan-1-one; 5-amino-1-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}pentan-1-one; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; N-(3-aminopropyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-N-[3-(dimethylamino)propyl]piperidine-1-carboxamide; 1-(4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)piperazine; 4-(4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine; 1-(4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-1,4-diazepane; ethyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; ethyl 1-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylic acid; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxamide; 4-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4 yl}carbonyl)morpholine; 1-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}methanol; 4-[1-(4-methyl-phenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methanol; [(3R)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl]methanol; methyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxylate; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxamide; 2-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}ethan-1-ol; methyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxylate; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxamide; 1-(1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-2-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]morpholine; 1-(4-chlorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-4-ol; N-butyl-1-(4-chlorophenyl)-N-methyl-1H-pyrazolo[3,4-c]pyridin-3-amine; 1-[4-(fluoromethyl)phenyl]-3-(oxan-4-yl)-1H-pyrazolo[3,4-c]pyridine; and 3-(4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-1-yl}methyl)pyridine are useful for the inhibition of SSAO activity.
    2-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}乙基-1-胺; 3-氨基丙基 4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酸酯; 1-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}-4-(二甲基氨基)丁酮; 5-氨基-1-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}戊酮; N-(2-氨基乙基)-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; N-(3-氨基丙基)-4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-羧酰胺; 4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]-N-[3-(二甲胺基)丙基]哌啶-1-羧酰胺; 1-(4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)哌嗪; 4-(4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)吗啉; 1-(4-[1-(4-氯苯基)-1H-吡咯并[2,3-c]吡啶-3-基]哌啶-1-基}羰基)-1,4-二氮杂环庚烷; 乙酸乙酯 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 乙酸乙酯 1-[1-(4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸酯; 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酸; N-(2-氨基乙基)-1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-羧酰胺; 4-(1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-基}羰基)吗啉; 1-(1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-4-基}羰基)哌嗪; 4-[1-(4-甲基苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基}甲醇; 4-[1-(4-甲基-苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-2-基}甲醇; [(3R)-4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基]甲醇; 甲酸甲酯 4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酸酯; N-(2-氨基乙基)-4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-羧酰胺; 2-4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]吗啉-3-基}乙基-1-醇; 甲酸甲酯 1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-羧酸酯; N-(2-氨基乙基)-1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-羧酰胺; 1-(1-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-2-基}羰基)哌嗪; 4-[1-(4-甲基苯基)-1H-吡咯并[2,3-c]吡啶-3-基]吗啉; 1-(4-氯苯基)-3-(哌啶-4-基)-1H-吡咯并[2,3-c]吡啶-4-醇; N-丁基-1-(4-氯苯基)-N-甲基-1H-吡唑并[3,4-c]吡啶-3-胺; 1-[4-(氟甲基)苯基]-3-(氧杂环丁基)-1H-吡唑并[3,4-c]吡啶; 和3-(4-[1-(4-氯苯基)-1H-吡唑并[3,4-c]吡啶-3-基]哌啶-1-基}甲基)吡啶可用于抑制SSAO活性。
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