N-acryloyl-salicylhydrazide | 1031422-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-acryloyl-salicylhydrazide
• 英文别名: H3acshz；2-Hydroxy-N'-(prop-2-enoyl)benzohydrazide；2-hydroxy-N'-prop-2-enoylbenzohydrazide
• CAS: 1031422-82-8
• 化学式: C₁₀H₁₀N₂O₃
• mdl: MFCD12035372
• 分子量: 206.201
• InChiKey: WCUFDERSSZEOJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-二甲基甲酰胺 、 nickel(II) chloride hexahydrate 、 N-acryloyl-salicylhydrazide 在 NaOH 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 [Ni3(H2O)2(DMA)2(acshz)2]*2DMF
  参考文献：
  名称：

  Synthesis, characterization and bioactivity of a new Fe(III) 18-metallacrown-6 and a new trinuclear linear Ni(II) complexes

  摘要：

  A new trinuclear linear Ni(II) compound [Ni(3)(H(2)O)(2)(DMA)(2)(acshz)(2)] center dot 2DMF (DMA = dimethylamine) (I) and a new Fc(III) 18-metallacrown-6 [Fe(6)(acbshz)(6)(DMF)(H(2)O)(5)] center dot 5DMF (2), with two similar pentadentate ligands, N-acryloyl-salicylhydrazide (H(3)acshz) and N-acryloyl-5-bromosalicylhydrazide (H(3)acbshz) have been synthesized and characterized by X-ray crystallography. In compound 1, three nickel ions arrange in a strictly linear structure, adjacent molecules are linked by intermolecular H bonds to form a 2D infinite wave-like structure. In compound 2, the ring of the metallacrown is consisted of six interlink [Fe-N-N] repeated units through hydrazide N-N group bridging. It is the first metallacrown that the coordination environments of metal ions in the cycle ring are different, and these differences make the two faces of the disc-shaped hexanuclear ring do not have opposite chiralities. The studies in solution integrity and stability of the metallacrown 2 show it is soluble and stable in DMF. UV-Vis titrations demonstrate the metallacrown 2 is stable in DMF even in the presence of excess metal ions. Antibacterial screening data indicate the two compounds all have antimicrobial activities against the tested microorganisms. The activities of metallacrown 2 are stronger than trinuclear compound 1. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2008.02.016