5-Chlor-1,2-dimethylpyrrol | 56454-33-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 5-Chlor-1,2-dimethylpyrrol
• 英文别名: 2-chloro-1,5-dimethyl-pyrrole；2-Chloro-1,5-dimethylpyrrole
• CAS: 56454-33-2
• 化学式: C₆H₈ClN
• 分子量: 129.589
• InChiKey: WQEMAMKFYWGSNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-氯-5-甲基吡咯 、 potassium amide 以5%的产率得到
  参考文献：
  名称：

  CORDELL G. A., J. ORG. CHEM. , 1975, 40, NO 22, 3161-3169

  摘要：

  DOI：

文献信息

• [EN] PESTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS PESTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013064518A1

  公开（公告）日：2013-05-10

  A compound of formula (I), wherein R1 to R4 are, for example, each hydrogen, R5 is, for example, an unsubstituted aromatic 6-membered heterocycle; R6 is, for example,hydrogen; R7 is,for example, hydrogen, cyano, hydroxyl, formyl, C1-C4-alkyl, C1-C4-alkoxy, C2-C4- alkenyl, or C2-C4-alkynyl; and A1 to A5 are, independently selected, from, for example, N, and C-H; and its use as a pesticidal agent.

  一种化合物的化学式（I），其中R1至R4分别为氢，R5为未取代的芳香6元杂环；R6为氢；R7为氢、氰基、羟基、甲酰基、C1-C4-烷基、C1-C4-烷氧基、C2-C4-烯基或C2-C4-炔基；A1至A5独立选择自N和C-H；以及其作为杀虫剂的用途。
• SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
  申请人：Vanderbilt University

  公开号：US20150216863A1

  公开（公告）日：2015-08-06

  In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  该发明涉及替代的双环烷氧基吡唑类似物、其衍生物和相关化合物，它们可用作代谢型谷氨酸受体亚型5（mGluR5）的正向变构调节剂；制备这些化合物的合成方法；包含这些化合物的制药组合物；以及使用这些化合物和组合物治疗与谷氨酸功能障碍相关的神经和精神障碍的方法。本摘要旨在作为特定领域搜索的扫描工具，不限制本发明。
• [EN] 4-FLUORO-(4-(4-BENZYL)PIPERIDIN-1-YL)(2-(PYRIMIDIN-4-YL)PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP46A1 INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] DÉRIVÉS DE 4-FLUORO-(4-(4-BENZYL)PIPÉRIDIN-1-YL)(2-(PYRIMIDIN-4-YL)PYRIDIN-3-YL)MÉTHANONE ET COMPOSÉS SIMILAIRES UTILISÉS EN TANT QU'INHIBITEURS DE CYP46A1 POUR LE TRAITEMENT D'AFFECTIONS NEURODÉGÉNÉRATIVES
  申请人：SAGE THERAPEUTICS INC

  公开号：WO2022115620A1

  公开（公告）日：2022-06-02

  The present invention refers to 4-Fluoro-(4-(4-Benzyl)piperidin-l-yl) (2-(pyrimidin-4-yl)pyridin-3-yl)methanone derivatives and similar compounds of formula (I) as CYP46A1 inhibitors for the treatment of neurodegenerative disorders, epilepsy, developmental and epileptic encephalopathies, psychiatric disorders, and spasms; Neurodegenerative disorders such as e.g. Alzheimer's disease, mild cognitive impairment, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral infarction, glaucoma, and multiple sclerosis; Psychiatric disorders such as e.g. schizophrenia, autism spectrum disorder, delusional disorder, schizoaffective disorder, and depression. An exemplary compound is e.g. (4-fluoro-4-(4-fluorobenzyl) piperidin-l-yl)(2-(py rim idin-4-yl)py rid in-3-y I) methanone (example 3, compound 1).

  本发明涉及公式（I）的4-氟-（4-（4-苄基）哌啶-1-基）（2-（嘧啶-4-基）吡啶-3-基）甲酮衍生物和类似化合物作为CYP46A1抑制剂，用于治疗神经退行性疾病、癫痫、发育性和癫痫性脑病、精神障碍和痉挛；神经退行性疾病，例如阿尔茨海默病、轻度认知障碍、亨廷顿病、帕金森病、肌萎缩性侧索硬化症、创伤性脑损伤、脑梗死、青光眼和多发性硬化症；精神障碍，例如精神分裂症、自闭症谱系障碍、妄想症、情感性精神障碍和抑郁症。一个示例化合物是例如（4-氟-4-（4-氟苄基）哌啶-1-基）（2-（嘧啶-4-基）吡啶-3-基）甲酮（示例3，化合物1）。
• COMPOSITION FOR FORMING ORGANIC SEMICONDUCTOR FILM, ORGANIC SEMICONDUCTOR FILM AND METHOD FOR PRODUCING SAME, AND ORGANIC SEMICONDUCTOR ELEMENT
  申请人：FUJIFILM Corporation

  公开号：EP3522243A1

  公开（公告）日：2019-08-07

  Provided are an organic semiconductor film-forming composition, an organic semiconductor film formed of the organic semiconductor film-forming composition, an organic semiconductor element, and a method of forming an organic semiconductor film. The organic semiconductor film-forming composition includes at least two organic semiconductors, in which one organic semiconductor is a low molecular weight organic semiconductor compound having a molecular weight of 5000 or lower, and another organic semiconductor is a fused heterocyclic compound represented by the specific Formula (1) that has a chemical structure different from that of the low molecular weight organic semiconductor compound and has a molecular weight of 3000 or lower.

  本发明提供了一种有机半导体成膜组合物、由有机半导体成膜组合物形成的有机半导体薄膜、有机半导体元件以及形成有机半导体薄膜的方法。有机半导体成膜组合物包括至少两种有机半导体，其中一种有机半导体是分子量为 5000 或更低的低分子量有机半导体化合物，另一种有机半导体是化学结构不同于低分子量有机半导体化合物且分子量为 3000 或更低的由具体式（1）表示的融合杂环化合物。
• Microcrystalline organic semiconductor film, organic semiconductor transistor, and method of manufacturing organic semiconductor transistor
  申请人：FUJIFILM Corporation

  公开号：US10985327B2

  公开（公告）日：2021-04-20

  Provided are an organic semiconductor film, an organic semiconductor transistor formed of the organic semiconductor film, and a method of manufacturing the organic semiconductor transistor. In the organic semiconductor film, the formation or propagation of cracks can be effectively suppressed even in a case where the organic semiconductor film is patterned or is exposed to high heat. Provided are an organic semiconductor film, an organic semiconductor transistor formed of the organic semiconductor film, and a method of manufacturing the organic semiconductor transistor. The microcrystalline organic semiconductor film includes a compound represented by the following Formula (1) that has a molecular weight of 3000 or lower and in which a crystal domain size is 1 nm to 100 nm. X, Y, and Z each independently represent a specific ring-constituting atom. R1 and R2 each independently represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, or a heteroaryl group. R3 and R4 each independently represent a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, or a heteroaryl group. m and n each independently represent an integer of 0 to 2.

  本发明提供了一种有机半导体薄膜、一种由该有机半导体薄膜形成的有机半导体晶体管以及一种制造该有机半导体晶体管的方法。在有机半导体薄膜中，即使在有机半导体薄膜被图案化或暴露于高热的情况下，也能有效抑制裂纹的形成或传播。 本发明提供了一种有机半导体薄膜、由该有机半导体薄膜形成的有机半导体晶体管以及该有机半导体晶体管的制造方法。微晶有机半导体薄膜包括由下式(1)表示的化合物，该化合物的分子量为 3000 或更低，其晶域尺寸为 1 nm 至 100 nm。 X、Y 和 Z 各自独立地代表一个特定的成环原子。R1 和 R2 各自独立地代表氢原子、烷基、烯基、炔基、芳基或杂芳基。R3 和 R4 各自独立地代表卤原子、烷基、烯基、炔基、芳基或杂芳基。