4-Chloro-6-methyl-N-tricyclo[3.3.1.13,7]dec-1-yl-2-pyrimidinamine | 351194-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Chloro-6-methyl-N-tricyclo[3.3.1.13,7]dec-1-yl-2-pyrimidinamine
• 英文别名: N-(1-adamantyl)-4-chloro-6-methylpyrimidin-2-amine
• CAS: 351194-26-8
• 化学式: C₁₅H₂₀ClN₃
• 分子量: 277.79
• InChiKey: SMNQDWUAHUAVJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NEW (1-ADAMANTYLAMINO)PYRIMIDINES AND METHOD OF THEIR PREPARATION<br/>[FR] NOUVELLES (1-ADAMANTYLAMINO)PYRIMIDINES ET PROCEDE DE PREPARATION DE CES DERNIERES
  申请人：FUNDACJA ROZWOJU DIAGNOSTYKI I

  公开号：WO2001074789A1

  公开（公告）日：2001-10-11

  New (1-adamantylamino)pyrimidines of formula (1), wherein R1, R2, R3 or R4 are adamantylamino group, methyl group or halogen atom, the compound of formula (1) containing one adamantylamino group and a substituent or substituents being methyl groups or halogen atoms at a position different from an ortho-position to the amino group, and salts thereof, and a method of preparation of these new compounds. Studies have shown, that the compounds stimulate secretion of TNF-α in some neoplastic cell lines.