N-(6-methoxypyridin-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide | 535960-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: N-(6-methoxypyridin-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide
• 英文别名: N-(6-methoxypyridin-3-yl)-1,2,4,5-tetrahydro-3-benzazepine-3-carboxamide
• CAS: 535960-84-0
• 化学式: C₁₇H₁₉N₃O₂
• 分子量: 297.357
• InChiKey: CKFLMEWMMCJTCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Therapeutic compounds
  申请人：——

  公开号：US20030149024A1

  公开（公告）日：2003-08-07

  The present invention provides compounds of Formula I: 1 wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula I.

  本发明提供了公式I的化合物：1其中X，R1，R2，R3，R4，R5和R6具有规范中定义的任何值，以及包含该化合物的制药组合物。该发明还提供了治疗方法以及用于制备公式I化合物的过程和中间体。
• BENZAZEPINE DERIVATIVES AND THEIR USE AS 5-HT LIGANDS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1451176A2

  公开（公告）日：2004-09-01
• US6861420B2
  申请人：——

  公开号：US6861420B2

  公开（公告）日：2005-03-01
• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSES THERAPEUTIQUES
  申请人：UPJOHN CO

  公开号：WO2003045940A2

  公开（公告）日：2003-06-05

  The present invention provides compounds of Formula (I): wherein X, R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of Formula (I).