1,1-diethyl-N-methyl-N-neopentylsilanamine | 1384953-88-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-diethyl-N-methyl-N-neopentylsilanamine
• CAS: 1384953-88-1
• 化学式: C₁₀H₂₅NSi
• 分子量: 187.401
• InChiKey: MGBLBQUVMMSALT-UHFFFAOYSA-N

物化性质

• 沸点：
  199.2±9.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1,1-diethyl-N-methyl-N-neopentylsilanamine 在 盐酸 、 碳酸氢钠 作用下， 以 乙醚 、 甲醇 、 水 为溶剂， 反应 3.0h， 以65%的产率得到(2,2-二甲基丙基)(甲基)胺盐酸盐
  参考文献：
  名称：

  Iridium-Catalyzed Reduction of Secondary Amides to Secondary Amines and Imines by Diethylsilane

  摘要：

  Catalytic reduction of secondary amides to imines and secondary amines has been achieved using readily available iridium catalysts such as [Ir(COE)(2)Cl](2) with diethylsilane as reductant. The stepwise reduction to secondary amine proceeds through an imine intermediate that can be isolated when only 2 equiv of silane is used. This system requires low catalyst loading and shows high efficiency (up to 1000 turnovers at room temperature with 99% conversion have been attained) and an appreciable level of functional group tolerance.

  DOI：

  10.1021/ja304547s
• 作为产物：
  描述：

  N-甲基三甲基乙酰胺 在 chlorobis(cyclooctene)-iridium(I) dimer 、 二乙基硅烷 作用下， 反应 72.0h， 以85%的产率得到1,1-diethyl-N-methyl-N-neopentylsilanamine
  参考文献：
  名称：

  Iridium-Catalyzed Reduction of Secondary Amides to Secondary Amines and Imines by Diethylsilane

  摘要：

  Catalytic reduction of secondary amides to imines and secondary amines has been achieved using readily available iridium catalysts such as [Ir(COE)(2)Cl](2) with diethylsilane as reductant. The stepwise reduction to secondary amine proceeds through an imine intermediate that can be isolated when only 2 equiv of silane is used. This system requires low catalyst loading and shows high efficiency (up to 1000 turnovers at room temperature with 99% conversion have been attained) and an appreciable level of functional group tolerance.

  DOI：

  10.1021/ja304547s