bis(4-hydroxy-6-methyl-2-oxo-2H-pyrid-3-yl)(3-nitrophenyl)methane | 132559-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(4-hydroxy-6-methyl-2-oxo-2H-pyrid-3-yl)(3-nitrophenyl)methane
• 英文别名: 3,3'-[(3-nitrophenyl)methylene]bis[4-hydroxy-6-methylpyridin-2(1H)-one]；3,3'-(3-nitrobenzylidene)bis[4-hydroxy-6-methylpyridin-2(1H)-one]；3,3'-((3-nitrophenyl)methylene)bis(4-hydroxy-6-methylpyridin-2(1H)-one)；4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-1H-pyridin-3-yl)-(3-nitrophenyl)methyl]-6-methyl-1H-pyridin-2-one
• CAS: 132559-99-0
• 化学式: C₁₉H₁₇N₃O₆
• 分子量: 383.36
• InChiKey: KSXKCWWLDIMKIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,3'-((3-nitrophenyl)methylene)bis(4-hydroxy-6-methyl-2H-pyran-2-one) 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 8.0h， 以72%的产率得到bis(4-hydroxy-6-methyl-2-oxo-2H-pyrid-3-yl)(3-nitrophenyl)methane
  参考文献：
  名称：

  Synthesis of Fused 2Н-Pyridin-2-ones under the Conditions of Multicomponent Hantzsch Reaction

  摘要：

  One-pot process was studied between a substituted 4-hydroxy-2H-pyran-2-one and aromatic aldehydes and ammonium acetate in the conditions of modified Hantzsch reaction in acid environment under thermal and microwave activation. Arylmethylenebis-4-hydroxy-2H-pyridin-2-ones, hydrochromenopyridinone, and their oxygen-containing heteroanalogs were isolated. A primary condensation was confirmed into bispyran-2-one adducts, and at the use of salicilaldehyde, into pyranochromene with subsequent recyclization of pyranone fragments in pyridinone ones.

  DOI：

  10.1134/s1070428018080092

文献信息

• A green and efficient synthesis of 3,3′-arylidenebis[4-hydroxy-6-methyl-2(1<i>H</i>)-3-pyridinone]s in water under microwave irradiation
  作者：Feng Shi、Longji Cao、Ning Ma、Ge Zhang、Rongshun Chen、Yajie Zhang、Shujiang Tu

  DOI：10.1002/jhet.210

  日期：——

  A series of 3,3′-arylidenebis[4-hydroxy-6-methyl-2(1H)-3-pyridinone]s were synthesized via three-component reactions of aromatic aldehydes, 4-hydroxy-6-methyl-2H-pyran-2-one, and ammonium acetate in water under microwave irradiation. This method has the advantages of environmental friendliness, short reaction time, high yields, and easy operation. This efficient synthesis not only offers an economical

  通过芳族醛的三组分反应合成了一系列3,3'-亚芳基双[4-羟基-6-甲基-2（1 H）-3-吡啶酮] s，4-羟基-6-甲基-2 H-吡喃-2-酮和微波辐射下的水中乙酸铵。该方法具有环境友好，反应时间短，收率高，操作简便的优点。这种有效的合成方法不仅为这类重要化合物提供了一种经济，绿色的合成策略，而且丰富了水中微波辅助合成方法的研究。J.杂环化​​学。（2010）。
• 4-amino-6-methyl-2-pyran-2-one. Preparation and reactions with aromatic aldehydes
  作者：Maria Cervera、Marcial Moreno-mañas、Roser Pleixats

  DOI：10.1016/s0040-4020(01)90086-9

  日期：1990.1