carbamoyloxy-phenyl-acetic acid | 52083-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: carbamoyloxy-phenyl-acetic acid
• 英文别名: Carbamoyloxy-phenyl-essigsaeure；Inakt. α-Carbaminyloxy-phenylessigsaeure；Carbaminyl-dl-mandelsaeure；Mandelsaeureurethan；2-Carbamoyloxy-2-phenylacetic acid
• CAS: 52083-97-3
• 化学式: C₉H₉NO₄
• 分子量: 195.175
• InChiKey: GWZTXXJYRWDKAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-hydroxy-5-phenylbarbitursaeure 在 水 作用下， 生成 carbamoyloxy-phenyl-acetic acid
  参考文献：
  名称：

  Aspelund, Acta Academiae Aboensis, Series B: Mathematica et Physica, 10, Nr. 8 <1936> 11

  摘要：

  DOI：

文献信息

• [EN] PHOTOSWITCHABLE HDAC INHIBITORS<br/>[FR] INHIBITEURS DE HDAC PHOTOCOMMUTABLES
  申请人：GEN HOSPITAL CORP

  公开号：WO2014160221A1

  公开（公告）日：2014-10-02

  This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.

  本发明涉及组蛋白去乙酰酶的光开关抑制剂及其使用方法。本发明提供了一种HDAC抑制剂，其具有具有短热弛豫动力学的蛋白质功能光开关调节剂。所述化合物为重氮化合物，包括取代或未取代的芳基或杂芳基环，其中至少一个环被一个或多个HDAC靶向元件取代。
• [EN] CARBOCYCLIC DERIVATIVES AND CONJUGATED DERIVATIVES THEREOF, AND THEIR USE IN VACCINES<br/>[FR] DÉRIVÉS CARBOCYCLIQUES ET LEURS DÉRIVÉS CONJUGUÉS, ET LEUR UTILISATION DANS DES VACCINS
  申请人：GLAXOSMITHKLINE BIOLOGICALS SA

  公开号：WO2020182635A1

  公开（公告）日：2020-09-17

  The invention is in the field of vaccines and relates to oligomers having a selected degree of polymerization, obtained by connecting together a number of carbocyclic repeating units, and to conjugated derivatives thereof. The oligomers and conjugated derivatives thereof of the invention also have a selected degree of acetylation. The derivatives of the invention are useful for the preparation of immunogenic compositions, e.g. in the form of a vaccine.

  这项发明涉及疫苗领域，涉及具有选定聚合度的寡聚体，通过连接一定数量的碳环重复单元而获得，并涉及其共轭衍生物。该发明的寡聚体及其共轭衍生物还具有选定的乙酰化程度。该发明的衍生物可用于制备免疫原性组合物，例如疫苗形式。
• [EN] METHODS FOR SYNTHESIZING MOLYBDOPTERIN PRECURSOR Z DERIVATIVES<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE DÉRIVÉS Z DE PRÉCURSEUR DE MOLYBDOPTÉRINE
  申请人：ALEXION PHARMA INC

  公开号：WO2012112922A1

  公开（公告）日：2012-08-23

  Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.

  本文提供了制备式(I)化合物的合成方法。本文还提供了制备式(XIII)化合物的合成方法。本公开还提供了式(I)和式(XIII)化合物的有用中间体、衍生物、前药和药用可接受的盐、溶剂合物和水合物。这些化合物可用于治疗与钼辅因子缺乏相关的疾病。
• [EN] PENTAVALENT VACCINE AGAINST NEISSERIA MENINGITIDIS COMPRISING A SYNTHETIC MEN A ANTIGEN<br/>[FR] VACCIN PENTAVALENT CONTRE NEISSERA MENINGITIDIS COMPRENANT UN ANTIGÈNE SYNTHÉTIQUE MEN A
  申请人：GLAXOSMITHKLINE BIOLOGICALS SA

  公开号：WO2022043238A1

  公开（公告）日：2022-03-03

  The inventors have identified a combined vaccine for immunisation against bacterial meningitis caused by multiple pathogens.

  发明家们已经确定了一种联合疫苗，用于预防由多种病原体引起的细菌性脑膜炎。
• Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Cox M. Jason

  公开号：US20080076773A1

  公开（公告）日：2008-03-27

  The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型的取代氨基哌啶，它是二肽基肽酶-IV酶（“DPP-IV酶”）的抑制剂，并且在治疗或预防DPP-IV酶参与的疾病，如糖尿病，尤其是2型糖尿病方面具有用处。本发明还涉及包含这些化合物的制药组合物，以及使用这些化合物和组合物在预防或治疗DPP-IV酶参与的这些疾病方面的用途。