5-benzyl-2-(2-chloro-anilino)-thiazol-4-one | 132857-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-benzyl-2-(2-chloro-anilino)-thiazol-4-one
• 英文别名: 2-<2-Chlor-phenylimino>-5-benzyl-thiazolidon-(4)；2-(2-Chlor-phenylimino)-5-benzyl-thiazolidon-(4)；5-Benzyl-2-(2-chlorophenyl)imino-1,3-thiazolidin-4-one；5-benzyl-2-(2-chlorophenyl)imino-1,3-thiazolidin-4-one
• CAS: 132857-11-5
• 化学式: C₁₆H₁₃ClN₂OS
• 分子量: 316.811
• InChiKey: INUNSZMUASZIFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-溴-3-苯基丙酸 、 邻氯苯基硫脲 在 sodium acetate 作用下， 生成 5-benzyl-2-(2-chloro-anilino)-thiazol-4-one
  参考文献：
  名称：

  Raval,B.K.; Trivedi,J.J., Journal of the Indian Chemical Society, 1960, vol. 37, p. 435 - 436

  摘要：

  DOI：

文献信息

• METHODS OF TREATING LEUKODYSTROPHIES
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：US20200061076A1

  公开（公告）日：2020-02-27

  Methods of treating leukodystrophy are provided. Accordingly there is provided a method of treating leukodystrophy in a subject, the method comprising administering to the subject a therapeutically effective amount of an agent capable of up-regulating activity and/or expression of a component participating in a Sigma-1 Receptor (Sig-1R) signaling pathway. Also provided are agents and methods of up-regulating activity of Sig-1R in a cell and treating a disease that can benefit from up-regulating activity of Sig-1R. Also provided are agents and methods of modulating activity of sonic hedgehog (SHH) in a cell and treating a disease that can benefit from modulating activity of SHH.
• Raval,B.K.; Trivedi,J.J., Journal of the Indian Chemical Society, 1960, vol. 37, p. 435 - 436
  作者：Raval,B.K.、Trivedi,J.J.

  DOI：——

  日期：——