2,4,6-trihydroxybenzohydrazide | 1056960-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4,6-trihydroxybenzohydrazide
• CAS: 1056960-47-4
• 化学式: C₇H₈N₂O₄
• 分子量: 184.152
• InChiKey: RDFXRXHTZUUWCZ-UHFFFAOYSA-N

物化性质

• 密度：
  1.640±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4,6-三羟基苯甲酸乙酯 在 一水合肼 作用下， 反应 2.0h， 生成 2,4,6-trihydroxybenzohydrazide
  参考文献：
  名称：

  酰肼席夫碱：DPPH自由基和超氧阴离子清除剂。

  摘要：

  评估酰肼席夫碱1-27的体外DPPH自由基和超氧阴离子清除活性。他们显示出不同程度的DPPH自由基清除活性，IC（50）值在31.25-473.59 µM之间。化合物8、2和10的IC（50）值分别为31.25±1.32、34.40±0.66和37.24±0.4 µM。标准没食子酸正丙酯显示IC（50）值为30.12±0.27 µM。酰肼1-27表现出体外超氧阴离子清除活性，IC（50）值在175.6-450.89 µM范围内。结果表明，酰肼8、2和10具有DPPH清除活性，与标准的没食子酸正丙酯相当，而酰肼1-27的清除超氧阴离子的活性低于标准的没食子酸正丙酯（IC（50）= 106.34 ±1.6 µM）。

  DOI：

  10.2174/157340612801216111

文献信息

• RUBBER COMPOSITION, TIRE, ADDITIVE, AND HYDRAZIDE COMPOUND
  申请人：Bridgestone Corporation

  公开号：EP3495415A1

  公开（公告）日：2019-06-12

  Provided is a rubber composition comprising: a rubber component containing diene-based rubber; a filler, and a compound represented by formula (I) below: (wherein: A is an aryl group and has at least two polar groups, which may be the same or different from each other; R1 and R2 are each independently at least one substituent selected from a group consisting of a hydrogen atom, an acyl group, an amide group, an alkyl group, a cycloalkyl group, and an aryl group; and further, the substituent may include one or more of O, S, and N atoms), so as to provide a rubber composition excellent in low heat generating property and wear resistance.

  本发明提供了一种橡胶组合物，其中包括：含有二烯基橡胶的橡胶组分、填料和下式 (I) 所代表的化合物： 其中A 是芳基，并具有至少两个极性基团，这两个极性基团可以彼此相同或不同；R1 和 R2 分别独立地具有至少一个取代基，该取代基可从氢原子、酰基、酰胺基、烷基、环烷基和芳基组成的组中选择；此外，取代基可包括一个或多个 O、S 和 N 原子），从而提供一种具有优异低发热性能和耐磨性的橡胶组合物。
• RUBBER COMPOSITION AND TIRE
  申请人：Bridgestone Corporation

  公开号：EP3805306A1

  公开（公告）日：2021-04-14

  Provided is a rubber composition having excellent low heat generating properties, wear resistance and processability. The disclosed rubber composition contains a rubber component containing diene rubber, a filler, at least one of compounds represented by the following formulas (I) and (II), and a plurality of fatty acid metal salts each having a different type of metal.

  所提供的橡胶组合物具有优异的低发热特性、耐磨性和加工性。 所公开的橡胶组合物包含一种含有二烯橡胶的橡胶成分、一种填料、至少一种由以下公式（I）和（II）表示的化合物，以及多种脂肪酸金属盐，每种金属盐都具有不同的金属类型。
• TIRE RUBBER COMPOSITION AND TIRE
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP3825356B1

  公开（公告）日：2022-05-04
• RUBBER COMPOSITION, TIRE, ADDITIVE AND HYDRAZIDE
  申请人：BRIDGESTONE CORPORATION

  公开号：US20190177513A1

  公开（公告）日：2019-06-13

  Provided is a rubber composition comprising: a rubber component containing diene-based rubber; a filler, and a compound represented by formula (I) below: (wherein: A is an aryl group and has at least two polar groups, which may be the same or different from each other; R 1 and R 2 are each independently at least one substituent selected from a group consisting of a hydrogen atom, an acyl group, an amide group, an alkyl group, a cycloalkyl group, and an aryl group; and further, the substituent may include one or more of O, S, and N atoms), so as to provide a rubber composition excellent in low heat generating property and wear resistance.
• ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20220002768A1

  公开（公告）日：2022-01-06

  Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.