(E)-1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene | 118509-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene
• 英文别名: (E)-4,5-dimethoxy-2,β-dinitro-styrene；(E)-4,5-Dimethoxy-2,β-dinitro-styrol；trans-2-(4,5-dimethoxy-2-nitrophenyl)-1-nitroethene；1,2-dimethoxy-4-nitro-5-[(E)-2-nitroethenyl]benzene
• CAS: 118509-95-8
• 化学式: C₁₀H₁₀N₂O₆
• 分子量: 254.199
• InChiKey: LUCVJGSTUQBGFD-ONEGZZNKSA-N

物化性质

• 沸点：
  459.4±45.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene 以95%的产率得到
  参考文献：
  名称：

  SINHABABU, A. K.;BORCHARDT, R. T., J. ORG. CHEM., 1983, 48, N 19, 3347-3349

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-dimethoxynitrostyrene 生成 (E)-1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene
  参考文献：
  名称：

  Whalley, Journal of the Chemical Society, 1954, p. 1651

  摘要：

  DOI：

文献信息

• Integrated sequencing device
  申请人：BBI BioSeq, Inc., Massachusetts corporation

  公开号：US20010046676A1

  公开（公告）日：2001-11-29

  The invention is based on the discovery that the sequence of monomers in a polymeric biomolecule can be determined in a self-contained, high pressure reaction and detection apparatus, without the need for fluid flow into or out from the apparatus. The pressure is used to control the activity of enzymes that digest the polymeric biomolecule to yield the individual monomers in the sequence in which they existed in the polymer. High pressures modulate enzyme kinetics by reversibly inhibiting those enzymatic processes which result in a higher average activation volume, when compared to the ground state, and reversibly accelerating those processes which have lower activation volumes than the ground state. Modulating the pressure allows the experimenter to precisely control the activity of the enzyme. Conditions can be found, for example, where the enzyme removes only one monomer (e.g., a nucleotide or amino acid) from the biomolecule before the pressure is again raised to a prohibitive level. The identity of the single released nucleotide or amino acid can be determined using a detector that is in communication with a probe in the detection zone within the reaction vessel.

  本发明基于以下发现：在一个独立的高压反应和检测装置中，可以确定聚合生物大分子中单体的序列，而不需要流体流入或流出该装置。压力用于控制酶的活性，这些酶可以消化聚合生物大分子，按照聚合物中单体存在的顺序产生单体。高压通过可逆地抑制那些导致平均活化体积高于基态的酶过程，以及可逆地加速那些活化体积低于基态的酶过程，从而调节酶的动力学。通过调节压力，实验人员可以精确控制酶的活性。例如，在压力再次升高到令人望而却步的水平之前，可以找到酶只从生物大分子中去除一个单体（如核苷酸或氨基酸）的条件。释放出的单个核苷酸或氨基酸的特性可通过检测器来确定，检测器与反应容器内检测区的探针相通。
• Peterson, John R.; Do, Hoang D.; Dunham, Andrew J., Canadian Journal of Chemistry, 1988, vol. 66, p. 1670 - 1674
  作者：Peterson, John R.、Do, Hoang D.、Dunham, Andrew J.

  DOI：——

  日期：——
• A Dimethoxy Substituted Harman and Other Compounds Derived from 5,6-Dimethoxyindole
  作者：Charles F. Huebner、Hyla Ames Troxell、Dorothy C. Schroeder

  DOI：10.1021/ja01119a030

  日期：1953.12
• RAJESWARI, SUNDARAMOORTHI;DROST, KEVIN J.;CAVA, MICHAEL P., HETEROCYCLES, 29,(1989) N, C. 415-418
  作者：RAJESWARI, SUNDARAMOORTHI、DROST, KEVIN J.、CAVA, MICHAEL P.

  DOI：——

  日期：——
• Systems and devices for photoablation
  申请人：Stolen Craig

  公开号：US20090054883A1

  公开（公告）日：2009-02-26

  The invention provides a catheter for optical ablation of tissue in a living body, the catheter including: a distal end; a proximal end; an elongate catheter body coupled between the distal end and the proximal end; a light emission device at the distal end and configured to emit an ablation light having characteristics selected to regulate an optically regulatable transcription control element operably linked to a nucleic acid sequence for a gene product, the expression of which gene product in cells directly or indirectly kills cells; and a projection control mechanism coupled to the light emission device and configured to control an effectively illuminated area where the optically regulatable transcription control element is effectively regulatable by the ablation light projected from the light emission device. Also provided is a system which includes the catheter, and methods to prevent, inhibit or treat AF which employ an expression cassette and/or one or more selected wavelengths of light.