N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-3-(1H-benzimidazol-2-yl)propanamide | 1075223-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-3-(1H-benzimidazol-2-yl)propanamide
• CAS: 1075223-92-5
• 化学式: C₂₁H₂₂FN₅OS
• 分子量: 411.503
• InChiKey: LEAJNFTZGBZELA-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP
  申请人：Tamura Yuusuke

  公开号：US20100075957A1

  公开（公告）日：2010-03-25

  This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R 2a and R 2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R 3 a , R 3 b , R 3 c and R 3 d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.
• US8168630B2
  申请人：——

  公开号：US8168630B2

  公开（公告）日：2012-05-01
• US8884062B2
  申请人：——

  公开号：US8884062B2

  公开（公告）日：2014-11-11