Di(3-acetylphenyl)methan | 43227-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Di(3-acetylphenyl)methan
• 英文别名: 1-[3-[(3-Acetylphenyl)methyl]phenyl]ethanone
• CAS: 43227-06-1
• 化学式: C₁₇H₁₆O₂
• 分子量: 252.313
• InChiKey: DBHPRZYFNXCERD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二氯甲烷 、 3-碘苯乙酮 在 bis(1,5-cyclooctadiene)nickel (0) 、 2,4,5,6-四(9H-咔唑-9-基)异酞腈 、 三乙胺 、 4,4'-二叔丁基-2,2'-二吡啶 作用下， 反应 20.5h， 以72%的产率得到Di(3-acetylphenyl)methan
  参考文献：
  名称：

  镍和光氧化还原催化的芳基卤化物与二氯甲烷的自由基还原还原交叉偶联

  摘要：

  已经开发出了在双重Ni /光氧化还原催化条件下利用二氯甲烷中新的氯甲烷自由基的第一种催化策略。与与金属还原剂相关的传统两电子还原方法相比，通过单电子方法的该方法可在异常温和的条件下（可见光，环境温度，无强碱）进行，并表现出互补的反应模式。它提供了范围广泛的许多官能团，包括烯基，该烯基在先前的路线中遭受环丙烷化。通过该转化可以容易地获得二芳基甲烷-d 2化合物。

  DOI：

  10.1021/acs.orglett.0c03248

文献信息

• New Methylenebisphenyl Compounds Useful in the Treatment of Inflammation
  申请人：Pelcman Benjamin

  公开号：US20100144872A1

  公开（公告）日：2010-06-10

  There is provided compounds of formula (I), wherein R x , R y , X 1 , X 2 , L 1 , L 2 , Y 1 and Y 2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of leukotriene C 4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.

  提供了式(I)的化合物，其中Rx、Ry、X1、X2、L1、L2、Y1和Y2的含义在说明中给出，以及其药学上可接受的盐。这些化合物在希望和/或需要抑制白三烯C4合酶活性的疾病治疗中非常有用，特别是在呼吸道疾病和/或炎症的治疗中。
• Small-molecule inhibitors of angiogenin and rnases and in vivo and in vitro methods of using same
  申请人：Shapiro Robert

  公开号：US20070032418A1

  公开（公告）日：2007-02-08

  Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.
• TEMPORARY ADHESIVE FOR PRODUCTION OF SEMICONDUCTOR DEVICE, AND ADHESIVE SUPPORT AND PRODUCTION METHOD OF SEMICONDUCTOR DEVICE USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20150184033A1

  公开（公告）日：2015-07-02

  The invention is directed to a temporary adhesive containing (A) a polymer compound having a radical polymerizable group in its side chain, (B) a radical polymerizable monomer, and (C) a heat radical polymerization initiator, and a production method of semiconductor device having a member processed including: adhering a first surface of a member to be processed to a substrate through an adhesive layer formed from the temporary adhesive; conducting a mechanical or chemical processing on a second surface which is different from the first surface of the member to be processed to obtain the member processed; and releasing the first surface of the member processed from the adhesive layer.
• US7264932B2
  申请人：——

  公开号：US7264932B2

  公开（公告）日：2007-09-04
• US9505953B2
  申请人：——

  公开号：US9505953B2

  公开（公告）日：2016-11-29