4-iodo-3-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)phenol | 1447963-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-iodo-3-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)phenol
• CAS: 1447963-01-0
• 化学式: C₁₆H₁₂BIN₂O
• 分子量: 386.0
• InChiKey: VETBLDOXXVZHHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.29
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-iodo-3-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)phenol 、 N-Boc-3-氨基丙基溴 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以60%的产率得到tert-butyl N-[3-[3-(2,4-diaza-3-boratricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaen-3-yl)-4-iodophenoxy]propyl]carbamate
  参考文献：
  名称：

  Solid-supported ortho-iodoarylboronic acid catalyst for direct amidation of carboxylic acids

  摘要：

  Amides are a ubiquitous class of organic compounds endowed with great utility. There is a need for simple and effective catalytic methods for their direct formation from carboxylic acids and amines as a way to avoid the use of coupling reagents. We have designed a recyclable resin-supported derivative of 5-methoxy-2-iodophenylboronic acid as a heterogeneous catalyst active in ambient conditions for promoting direct amidations of aliphatic carboxylic acids and amines. The optimal, practical procedure involves a simple double-filtration to isolate the amide product while separating the catalyst from residual molecular sieves. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.043
• 作为产物：
  描述：

  2-碘-5-甲氧基苯硼酸 在 三溴化硼 作用下， 以 正庚烷 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 24.0h， 生成 4-iodo-3-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)phenol
  参考文献：
  名称：

  Solid-supported ortho-iodoarylboronic acid catalyst for direct amidation of carboxylic acids

  摘要：

  Amides are a ubiquitous class of organic compounds endowed with great utility. There is a need for simple and effective catalytic methods for their direct formation from carboxylic acids and amines as a way to avoid the use of coupling reagents. We have designed a recyclable resin-supported derivative of 5-methoxy-2-iodophenylboronic acid as a heterogeneous catalyst active in ambient conditions for promoting direct amidations of aliphatic carboxylic acids and amines. The optimal, practical procedure involves a simple double-filtration to isolate the amide product while separating the catalyst from residual molecular sieves. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.043