(1-methylpyridin-1-ium-2-yl) benzoate;iodide | 342815-17-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-methylpyridin-1-ium-2-yl) benzoate;iodide
• CAS: 342815-17-2
• 化学式: C₁₃H₁₂NO₂*I
• 分子量: 341.148
• InChiKey: HMJKIDKNMPGZIE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.27
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30.18
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (1-methylpyridin-1-ium-2-yl) benzoate;iodide 在 水 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 苯甲酸
  参考文献：
  名称：

  Selective deprotection and amidation of 2-pyridyl esters via N-methylation

  摘要：

  The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain intact. The N-methylated active esters can be subsequently transformed into amides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.016
• 作为产物：
  描述：

  2-pyridyl benzoate 、 碘甲烷 反应 6.0h， 生成 (1-methylpyridin-1-ium-2-yl) benzoate;iodide
  参考文献：
  名称：

  Selective deprotection and amidation of 2-pyridyl esters via N-methylation

  摘要：

  The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain intact. The N-methylated active esters can be subsequently transformed into amides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.016

文献信息

• MUKAIYAMA TERUAKI; USUI MASAHIRO; SHIMADA EIICHIRO; SAIGO KAZUHIKO, CHEM. LETT., 1975, NO 10, 1045-1048
  作者：MUKAIYAMA TERUAKI、 USUI MASAHIRO、 SHIMADA EIICHIRO、 SAIGO KAZUHIKO

  DOI：——

  日期：——