1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-2-thiophenylacrylamido]-2,5-dideoxy-L-iditol | 1273258-59-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-2-thiophenylacrylamido]-2,5-dideoxy-L-iditol
• CAS: 1273258-59-5
• 化学式: C₂₄H₂₆N₄O₆S₂
• 分子量: 530.626
• InChiKey: KUYQGQMXYBDARF-VSTHUOTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.23
• 重原子数：
  36.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  134.86
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  (Z)-2-Methyl-5-oxo-4-(2-thienylmethylene)-4,5-dihydro-1,3-oxazole 、 2,5-二氨基-1,4:3,6-二去氢-2,5-二脱氧己糖醇 以 乙酸乙酯 为溶剂， 以70%的产率得到1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-2-thiophenylacrylamido]-2,5-dideoxy-L-iditol
  参考文献：
  名称：

  Pseudo-peptides derived from isomannide: inhibitors of serine proteases

  摘要：

  In this paper, we describe the synthesis of a novel class of pseudo-peptides derived from isomannide and several oxazolones as potential inhibitors of serine proteases as well as preliminary pharmacological assays for hepatitis C. Hepatitis C, dengue and West Nile fever are among the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes and are a primary target in the drug development field. Several pseudo-peptides were obtained in good yields from the reaction of isomannide and oxazolones, and their anti-HCV potential using the HCV replicon-based assay was shown.

  DOI：

  10.1007/s00726-009-0273-4