N-acryloyl-5-bromosalicylhydrazide | 1031422-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-acryloyl-5-bromosalicylhydrazide
• 英文别名: H3acbshz；5-bromo-2-hydroxy-N'-prop-2-enoylbenzohydrazide
• CAS: 1031422-83-9
• 化学式: C₁₀H₉BrN₂O₃
• 分子量: 285.097
• InChiKey: FODWSPPINCUVCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Iron(III) nitrate nonahydrate 、 N-acryloyl-5-bromosalicylhydrazide 、 N,N-二甲基甲酰胺 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 以75.4%的产率得到[Fe6(N-acryloyl-5-bromosalicylhydrazide(-3H))6(N,N-dimethylformamide)(H2O)5]*5(N,N-dimethylformamide)
  参考文献：
  名称：

  Synthesis, characterization and bioactivity of a new Fe(III) 18-metallacrown-6 and a new trinuclear linear Ni(II) complexes

  摘要：

  A new trinuclear linear Ni(II) compound [Ni(3)(H(2)O)(2)(DMA)(2)(acshz)(2)] center dot 2DMF (DMA = dimethylamine) (I) and a new Fc(III) 18-metallacrown-6 [Fe(6)(acbshz)(6)(DMF)(H(2)O)(5)] center dot 5DMF (2), with two similar pentadentate ligands, N-acryloyl-salicylhydrazide (H(3)acshz) and N-acryloyl-5-bromosalicylhydrazide (H(3)acbshz) have been synthesized and characterized by X-ray crystallography. In compound 1, three nickel ions arrange in a strictly linear structure, adjacent molecules are linked by intermolecular H bonds to form a 2D infinite wave-like structure. In compound 2, the ring of the metallacrown is consisted of six interlink [Fe-N-N] repeated units through hydrazide N-N group bridging. It is the first metallacrown that the coordination environments of metal ions in the cycle ring are different, and these differences make the two faces of the disc-shaped hexanuclear ring do not have opposite chiralities. The studies in solution integrity and stability of the metallacrown 2 show it is soluble and stable in DMF. UV-Vis titrations demonstrate the metallacrown 2 is stable in DMF even in the presence of excess metal ions. Antibacterial screening data indicate the two compounds all have antimicrobial activities against the tested microorganisms. The activities of metallacrown 2 are stronger than trinuclear compound 1. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2008.02.016

文献信息

• Synthesis, crystal structure and bioactivity of a novel linear trinuclear nickel(II) complex
  作者：Wei Luo、Xianggao Meng、Xuzhuo Sun、Fengping Xiao、Junfeng Shen、Yan Zhou、Gongzhen Cheng、Zhenping Ji

  DOI：10.1016/j.inoche.2007.07.022

  日期：2007.11

  Abstract A novel linear trinuclear nickel(II) complex, [Ni3(H2O)2(DMA)2(acbshz)2]·2DMF (DMA = dimethylamine; acbshz = N-acryloyl-5-bromosalicylhydrazide), has been prepared by self-assembly approach. The three nickel atoms arrange in a strictly linear structure, adjacent molecules are linked by intermolecular H bonds to form a 2D infinite wave-like structure. Antibacterial screening data indicate the

  摘要 一种新型线性三核镍(II)配合物，[Ni3(H2O)2(DMA)2(acbshz)2]·2DMF（DMA = 二甲胺；acbshz = N-丙烯酰-5-溴水杨酰肼），通过自氧化法制备。组装方法。三个镍原子以严格的线性结构排列，相邻的分子通过分子间H键连接形成二维无限波浪状结构。抗菌筛选数据表明，三核复合物的形成降低了配体的抗菌活性。