N-(1,4-dihydro-2,3-benzodithiin-6-yl)-4-phenylbenzenesulfonamide | 1167515-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1,4-dihydro-2,3-benzodithiin-6-yl)-4-phenylbenzenesulfonamide
• CAS: 1167515-56-1
• 化学式: C₂₀H₁₇NO₂S₃
• 分子量: 399.558
• InChiKey: YFPGVRGCXTZFCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-amino-1,4-dihydro-benzo[d][1,2]dithiine 、 对联苯磺酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到N-(1,4-dihydro-2,3-benzodithiin-6-yl)-4-phenylbenzenesulfonamide
  参考文献：
  名称：

  Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives

  摘要：

  A convenient method to prepare a series of benzodithiine derivatives was developed, via the synthesis of cyclic disulfide building blocks containing an amino-group linker. Some of the novel cyclic disulfide compounds are shown to modulate the activity of the redox-enzyme glutathione reductase. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.209

文献信息

• Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives
  作者：Sandraliz Espinosa、Melissa Solivan、Cornelis P. Vlaar

  DOI：10.1016/j.tetlet.2009.03.209

  日期：2009.6

  A convenient method to prepare a series of benzodithiine derivatives was developed, via the synthesis of cyclic disulfide building blocks containing an amino-group linker. Some of the novel cyclic disulfide compounds are shown to modulate the activity of the redox-enzyme glutathione reductase. (C) 2009 Elsevier Ltd. All rights reserved.