12β-acetoxy-3-oxo-5β-cholan-24-oic acid methyl ester | 107329-64-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 12β-acetoxy-3-oxo-5β-cholan-24-oic acid methyl ester
• 英文别名: 12β-Acetoxy-3-oxo-5β-cholan-24-saeure-methylester；12β-Acetoxy-3-oxo-5β-cholansaeure-(24)-methylester；methyl (4R)-4-[(5R,8R,9S,10S,12R,13R,14S,17R)-12-acetyloxy-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoate
• CAS: 107329-64-6
• 化学式: C₂₇H₄₂O₅
• 分子量: 446.627
• InChiKey: KNHGHMDIHVHLKX-DXTSGOFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  12β-acetoxy-3-oxo-5β-cholan-24-oic acid methyl ester 在 sodium ethanolate 、 一水合肼 作用下， 生成 (5beta,12beta)-12-羟基胆烷-24-酸
  参考文献：
  名称：

  Arrhythmias during spinal anesthesia for Cesarean section

  摘要：

  Purpose: Spinal block has long been considered a safe anesthesia technique for surgery. However, severe bradycardia, cardiac arrest, and other arrhythmias during spinal anesthesia have been reported and the incidence of intraoperative arrhythmias is not well established. In this study the incidence of arrhythmias during spinal anesthesia was determined.Methods: We studied 254 healthy women undergoing Cesarean section under spinal anesthesia prospectively. Spinal anesthesia with 10 mg bupivacaine mixed with 0.2 mg morphine was performed at the L3-4 interspace. Intraoperative arrhythmias were recorded and verified later by a cardiologist.Results: First degree atrioventricular block developed in nine patients (3.5%), second degree atrioventricular block in nine (3.5%), severe bradycardia (heart rate < 50 beats.min(-1)) in seventeen (6.7%), multiple VPC in three (1.2%). The height and weight of patients with severe bradycardia, multiple VPCs, or atrioventricular block were not different from those of the other patients. However, the age of patients in the potentially dangerous arrhythmias group was greater than that in the other group (P = 0.006).Conclusion: The incidence of arrhythmias as well as hypotension during spinal anesthesia for Cesarean section was higher than expected. Although most of these arrhythmias were transient and recovered spontaneously, they might unexpectedly occur and sometimes need immediate and prompt treatment. it is necessary to remain vigilant during spinal anesthesia for Cesarean section and careful monitoring of these patients is warranted, especially in older parturients.

  DOI：

  10.1007/bf03018966
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 12β-acetoxy-3-oxo-5β-cholan-24-oic acid methyl ester
  参考文献：
  名称：

  ÜberGallensäuren和veroffdte Stoffe。16. Mitteilung。3α，12α-Dioxy-cholansäure（12- epi - Desoxycholsäure）

  摘要：

  DOI：

  10.1002/hlca.19420250516