[(2R,3S,4R,5R,6S)-5-[(2-diphenylphosphanylbenzoyl)amino]-3-hydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-4-yl] 2-diphenylphosphanylbenzoate | 1044598-13-1

• 分子结构分类: 有机化合物
• 英文名称: [(2R,3S,4R,5R,6S)-5-[(2-diphenylphosphanylbenzoyl)amino]-3-hydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-4-yl] 2-diphenylphosphanylbenzoate
• CAS: 1044598-13-1
• 化学式: C₅₁H₄₅NO₇P₂
• 分子量: 845.868
• InChiKey: MGCNOZZGTVFIIU-XYIHAIEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  61
• 可旋转键数：
  15
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [(2R,3S,4R,5R,6S)-5-[(2-diphenylphosphanylbenzoyl)amino]-3-hydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-4-yl] 2-diphenylphosphanylbenzoate 在 三乙胺 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 naplephos-a''
  参考文献：
  名称：

  New tagged naplephos ligands for asymmetric allylic substitutions under traditional and unconventional conditions

  摘要：

  This paper demonstrates the versatility of the class of chiral ligands naplephos, which has been further refined by preparing new 'tagged' versions for selective use in polar media (e.g., ionic liquids). These modified types, along with the best performing original varieties, have been examined in two Pd-catalysed asymmetric processes involving C-C and C-N bond formation. High ees have been achieved in traditional solvents, while the experiments performed in ionic liquids confirm the difficulty of predicting the outcome of a reaction in these media and the general decrease in the catalytic performance. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.05.013