3-[[4-[2-[benzyl[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)-5-methylbenzoic acid | 870103-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-[[4-[2-[benzyl[(2R)-2-(6-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl]-2-(benzyloxy)-5-methylbenzoic acid
• 英文别名: 3-[4-[2-[benzyl-[(2R)-2-(6-chloropyridin-3-yl)-2-hydroxyethyl]amino]ethyl]phenyl]sulfonyl-5-methyl-2-phenylmethoxybenzoic acid
• CAS: 870103-93-8
• 化学式: C₃₇H₃₅ClN₂O₆S
• 分子量: 671.214
• InChiKey: DZXJMJNMKXSWSU-XIFFEERXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  47
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] AMINOALCOHOL DERIVATIVES<br/>[FR] DÉRIVÉS D'AMINOALCOOLS
  申请人：ASTELLAS PHARMA INC

  公开号：WO2005110981A1

  公开（公告）日：2005-11-24

  The present invention relates to a compound formula[I]: wherein X is bond or -O-, R1 is formula[A] or formula [B] in which R5, R6 and R7 are each as defined in the description, R2 is hydrogen or lower alkyl, R3 is hydrogen or an amino protective group , R4 is formula[C], [D] or [E] in which R8, R9, R10, R11, R12, R13 and R16 are each as defined in the description, and R14 and R15 are each independently hydrogen or lower alkyl, or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of overactive bladder, micturiation disorder and the like.

  本发明涉及一种化合物公式[I]：其中X是键或-O-，R1是公式[A]或公式[B]，其中R5、R6和R7如描述中所定义，R2是氢或低碳基，R3是氢或氨基保护基，R4是公式[C]、[D]或[E]，其中R8、R9、R10、R11、R12、R13和R16如描述中所定义，R14和R15各自独立地是氢或低碳基，或其前药或盐。本发明的化合物[I]及其药学上可接受的盐对于预防和/或治疗过度活跃膀胱、排尿障碍等方面是有用的。