4-methoxy-4'-phenoxy-benzhydrylamine | 854184-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-4'-phenoxy-benzhydrylamine
• 英文别名: (4-Methoxyphenyl)-(4-phenoxyphenyl)methanamine
• CAS: 854184-88-6
• 化学式: C₂₀H₁₉NO₂
• 分子量: 305.376
• InChiKey: HIAYYPONQHZSIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.54
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  44.48
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-methoxy-4'-phenoxy-benzhydrylamine 生成 N-(4-methoxy-4'-phenoxy-benzhydryl)-acetamide
  参考文献：
  名称：

  Patwardhan; Phalnikar; Bhide, Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1949, vol. 18/A, p. 22

  摘要：

  DOI：
• 作为产物：
  描述：

  4-methoxy-4'-phenoxy-benzophenone oxime 在 乙醇 、 sodium 作用下， 生成 4-methoxy-4'-phenoxy-benzhydrylamine
  参考文献：
  名称：

  Patwardhan; Phalnikar; Bhide, Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1949, vol. 18/A, p. 22

  摘要：

  DOI：

文献信息

• PEPTIDE SYNTHESIS METHOD
  申请人：JITSUBO Co., Ltd.

  公开号：US20210139532A1

  公开（公告）日：2021-05-13

  The present invention has an object of shortening the process time and reducing use of a poor solvent for solidifying a carrier (Tag)-peptide component, by removing impurities without conducting solid-liquid separation (condensation, solid-liquid separation and drying operation) of a Tag-peptide component, in an Fmoc method using a Tag for liquid phase peptide synthesis. Provided is the peptide synthesis method that includes the following steps a-d: step a: a carrier-protected amino acid, carrier-protected peptide, or a carrier-protected amino acid amide, and an N-Fmoc-protected amino acid or an N-Fmoc-protected peptide are condensed in an organic solvent or a mixed solution of organic solvents, to obtain an N-Fmoc-carrier-protected peptide, step b: a water-soluble amine is added to the reaction solution after the condensation reaction, step c: the Fmoc group is deprotected from the protected amino group in the presence of a water-soluble amine, and step d: the reaction solution is neutralized by adding an acid, and further, by adding and washing with an acidic aqueous solution, then, by liquid-liquid separation an aqueous layer is removed to obtain an organic layer.