2-bromo-3-(2-(tert-butyldimethylsiloxy)ethyl)thiophene | 893441-71-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 2-bromo-3-(2-(tert-butyldimethylsiloxy)ethyl)thiophene
• 英文别名: (2-(2-bromothiophen-3-yl)ethoxy)(tert-butyl)dimethylsilane；2-(2-bromothiophen-3-yl)ethoxy-tert-butyl-dimethylsilane
• CAS: 893441-71-9
• 化学式: C₁₂H₂₁BrOSSi
• 分子量: 321.354
• InChiKey: APHODHBPTVZNAL-UHFFFAOYSA-N

物化性质

• 沸点：
  310.7±32.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-3-(2-(tert-butyldimethylsiloxy)ethyl)thiophene 以 四氢呋喃 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  供体-受体二元体中序列定义的共轭低聚物

  摘要：

  共轭大分子在化学领域有着丰富的历史，因为它们的化学排列将物理和电子特性交织在一起。然而，这些系统的持续研究和应用需要开发原子级精确模型，以弥合分子、聚合物和/或其混合物之间的差距。一类促进结构-性能关系发展的共轭聚合物是离散的、精密的低聚物，它仍然是一个突出的合成挑战，只有少数报道的例子。在这里，我们展示了分子二元体的首次合成，其特征是序列定义的低聚噻吩供体与小分子受体共价连接。这些二元体作为探测涉及序列定义的低聚物的复杂光物理相互作用的平台。通过对相对于受体单元的寡聚噻吩长度和序列依赖性排列进行前所未有的控制，可以促进这种评估，通过序列定义的寡聚化，在沿着主链的精确位置掺入含羟基侧链，使之成为可能。我们表明，低聚噻吩序列和长度在决定光激发态的转移效率方面发挥互补作用。总的来说，这项工作强调了供体-受体系统空间排列的重要性，这些系统通常被研究用于一系列用途，包括光捕获和光催化。

  DOI：

  10.1021/jacs.3c06923
• 作为产物：
  描述：

  tert-butyl-dimethyl-[2-(3-thienyl)ethoxy]silane 在 N-溴代丁二酰亚胺(NBS) 作用下， 生成 2-bromo-3-(2-(tert-butyldimethylsiloxy)ethyl)thiophene
  参考文献：
  名称：

  Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor

  摘要：

  Targeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series of benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors. The antiviral activity and spectrum of this class was significantly improved by exploring the amino substitution of the pyridine ring, resulting in the discovery of the most potent RSV A polymerase inhibitors reported to date. (C) 2013 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2013.10.018

文献信息

• [EN] DIHYDROPYRIMIDINE COMPOUND AND APPLICATION THEREOF<br/>[FR] COMPOSÉ DIHYDROPYRIMIDINE ET SON UTILISATION<br/>[ZH] 二氢嘧啶类化合物、其应用
  申请人：HEPAGENE THERAPEUTICS HK LTD

  公开号：WO2022052923A1

  公开（公告）日：2022-03-17

  提供了一种如式(I)所示的二氢嘧啶类化合物、其互变异构体或其药学上可接受的盐、及其应用。该二氢嘧啶类化合物具有较好的抗HBV活性，可用于制备治疗和/或预防HBV感染的药物。
• AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
  申请人：Smith Adrian Leonard

  公开号：US20100010014A1

  公开（公告）日：2010-01-14

  The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

  本发明涉及氨基嘧啶化合物，可用于治疗由极化样激酶1（Plk1）介导的疾病。本发明还涉及在治疗与异常细胞生长和不必要的细胞增殖相关的疾病状态中，使用这种氨基嘧啶化合物及其组合物的治疗用途。
• Aminopyrimidine compounds and methods of use
  申请人：Smith Leonard Adrian

  公开号：US20070185133A1

  公开（公告）日：2007-08-09

  The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

  本发明涉及氨基嘧啶化合物，用于治疗由波洛样激酶1（Plk1）介导的疾病。本发明还涉及这种氨基嘧啶化合物及其组成物在治疗与异常细胞生长和不必要的细胞增殖相关的疾病状态中的治疗用途。
• WO2006/66172
  申请人：——

  公开号：——

  公开（公告）日：——
• Live-Cell-Permeant Thiophene Fluorophores and Cell-Mediated Formation of Fluorescent Fibrils
  作者：Ilaria Palamà、Francesca Di Maria、Ilenia Viola、Eduardo Fabiano、Giuseppe Gigli、Cristian Bettini、Giovanna Barbarella

  DOI：10.1021/ja2065522

  日期：2011.11.9

  In our search for thiophene fluorophores that can overcome the limits of currently available organic dyes in live-cell staining, we synthesized biocompatible dithienothiophene-S,S-dioxide derivatives' (DTTOs). that were spontaneously taken up by live mouse embryonic fibroblasts and HeLa cells. Upon treatment with DTTOs, the cells secreted nanostructured fluorescent fibrils, while cell viability remained unaltered. Comparison with the behavior of Other cell-permeant, newly synthesized thiophene fluorophores showed that the formation of fluorescent fibrils was peculiar to DTTO dyes. Laser scanning confocal microscopy of the fluorescent fibrils showed that most of them were characterized by helical supramolecular organization. Electrophoretic analysis and theoretical calculations suggested that the DTTOs were selectively recognized by the HyPro component of procollagen polypeptide chains and incorporated through the formation of multiple H-bondings.