tert-butyl N-[10-(methylamino)decyl]carbamate | 1072920-61-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[10-(methylamino)decyl]carbamate
• CAS: 1072920-61-6
• 化学式: C₁₆H₃₄N₂O₂
• 分子量: 286.458
• InChiKey: ICJZSYVOOMYVFI-UHFFFAOYSA-N

物化性质

• 沸点：
  382.3±15.0 °C(Predicted)
• 密度：
  0.912±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 tert-butyl N-[10-(methylamino)decyl]carbamate 、 柚皮素 以 乙醇 为溶剂， 以74%的产率得到tert-butyl N-[10-[[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-6-yl]methyl-methylamino]decyl]carbamate
  参考文献：
  名称：

  Site-Specific Fluorescent Labeling Approaches for Naringenin, an Essential Flavonone in Plant Nitrogen-Fixation Signaling Pathways

  摘要：

  In search of an appropriate position for the fluorescent labeling. six chemically available positions of the flavonone core of naringenin have been examined. A number of azido-containing naringenin derivatives were accordingly prepared in various site-specific fashions. and the Mild CU(I)-catalyzed Huisgen 1-3-dipolar cycloaddition successfully served as the common "Click" labeling tool in the final steps. Oil the basis of the biological activities of the first batch of labeled compounds, further optimization at the C-6 position of naringenin finally afforded naringenin-flu (27). which acquired 20% of the potency of naringenin and presented good optical properties. Entry of naringenin-flu into living Rhizobium Cells was demonstrated by in vitro fluorescent imaging experiments.

  DOI：

  10.1021/jo8014165

文献信息

• Chemokine receptor binding heterocyclic compounds
  申请人：Bridger James Gary

  公开号：US20070060591A1

  公开（公告）日：2007-03-15

  The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.

  本发明涉及新型抗病毒化合物、药物组合物及其用途。更具体地说，本发明涉及单环多胺衍生物，在针对HIV或FIV感染的细胞的标准测试中具有活性，以及与结合配体到介导多种哺乳动物胚胎发育过程的趋化因子受体相关的其他生物活性。
• Site-Specific Fluorescent Labeling Approaches for Naringenin, an Essential Flavonone in Plant Nitrogen-Fixation Signaling Pathways
  作者：Lei Chen、Feng-Qing Li、Bi-He Hou、Guo-Fan Hong、Zhu-Jun Yao

  DOI：10.1021/jo8014165

  日期：2008.11.7

  In search of an appropriate position for the fluorescent labeling. six chemically available positions of the flavonone core of naringenin have been examined. A number of azido-containing naringenin derivatives were accordingly prepared in various site-specific fashions. and the Mild CU(I)-catalyzed Huisgen 1-3-dipolar cycloaddition successfully served as the common "Click" labeling tool in the final steps. Oil the basis of the biological activities of the first batch of labeled compounds, further optimization at the C-6 position of naringenin finally afforded naringenin-flu (27). which acquired 20% of the potency of naringenin and presented good optical properties. Entry of naringenin-flu into living Rhizobium Cells was demonstrated by in vitro fluorescent imaging experiments.