5-tert-butyl 1-ethyl 3-{[4-(4-cyclopropylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate | 827318-62-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-tert-butyl 1-ethyl 3-{[4-(4-cyclopropylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• 英文别名: 5-O-tert-butyl 1-O-ethyl 3-[[4-(4-cyclopropylpiperazin-1-yl)benzoyl]amino]-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate
• CAS: 827318-62-7
• 化学式: C₂₇H₃₆N₆O₅
• 分子量: 524.62
• InChiKey: BPOZFBVGNIKQLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
  申请人：Fancelli Daniele

  公开号：US20050032839A1

  公开（公告）日：2005-02-10

  Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本文披露了式(I)及其药学上可接受的盐的吡咯并[3,4-c]吡唑衍生物，以及其制备方法和包含它们的药物组合物；本发明的化合物可能在治疗与蛋白激酶活性失调有关的疾病，如癌症方面有用。
• PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：EP1644376B1

  公开（公告）日：2010-09-08
• US7141568B2
  申请人：——

  公开号：US7141568B2

  公开（公告）日：2006-11-28
• US7582628B2
  申请人：——

  公开号：US7582628B2

  公开（公告）日：2009-09-01
• [EN] PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DERIVES DU PYRROLO[3,4-C]PYRAZOLE ACTIFS COMME INHIBITEURS DES KINASES
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2005005427A1

  公开（公告）日：2005-01-20

  [EN] Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
  [FR] L'invention porte: sur des dérivés du pyrrolo[3,4-c]pyrazole de formule (I) et leurs sels pharmacocompatibles, tels que définis dans la spécification; sur leur procédé de préparation; et sur des préparations pharmaceutiques les comprenant. Lesdits composés peuvent servir en thérapie au traitement de maladies, associées à un dérèglement de l'activité des protéines kinases, telles que le cancer.