(2S)-1-[benzyl(prop-2-enyl)amino]propan-2-ol | 150302-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-1-[benzyl(prop-2-enyl)amino]propan-2-ol
• CAS: 150302-32-2
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: XENJVEVTGLRGQO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-1-[benzyl(prop-2-enyl)amino]propan-2-ol 在 lithium tetrachloropalladate 、 copper dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 (2R,6S)-4-Benzyl-2-(chloromethyl)-6-methylmorpholine 、 (2S,6S)-4-Benzyl-2-(chloromethyl)-6-methylmorpholine
  参考文献：
  名称：

  Stereochemistry and regiochemistry of heteroatom directed reactions. Part 4. Palladium(II)-catalyzed synthesis of optically active tetrahydro-1,4-oxazine derivatives

  摘要：

  Three different types of morpholine derivatives 1-3 could be obtained from allylic amine substrates 4 in high yield and excellent diastereoselectivity by slight, variation of the Pd(II)-Cu(II) reagents system.

  DOI：

  10.1021/jo00070a001
• 作为产物：
  描述：

  (S)-N-benzyl-2-hydroxypropionamide 在 lithium aluminium tetrahydride 作用下， 生成 (2S)-1-[benzyl(prop-2-enyl)amino]propan-2-ol
  参考文献：
  名称：

  Stereochemistry and regiochemistry of heteroatom directed reactions. Part 4. Palladium(II)-catalyzed synthesis of optically active tetrahydro-1,4-oxazine derivatives

  摘要：

  Three different types of morpholine derivatives 1-3 could be obtained from allylic amine substrates 4 in high yield and excellent diastereoselectivity by slight, variation of the Pd(II)-Cu(II) reagents system.

  DOI：

  10.1021/jo00070a001

文献信息

• Stereochemistry and regiochemistry of heteroatom directed reactions. Part 4. Palladium(II)-catalyzed synthesis of optically active tetrahydro-1,4-oxazine derivatives
  作者：Jinyu Lai、Xiaoxin Shi、Yanshen Gong、Lixin Dai

  DOI：10.1021/jo00070a001

  日期：1993.8

  Three different types of morpholine derivatives 1-3 could be obtained from allylic amine substrates 4 in high yield and excellent diastereoselectivity by slight, variation of the Pd(II)-Cu(II) reagents system.