4-O-羧甲基壳二孢氯素 | 84435-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-O-羧甲基壳二孢氯素
• 英文名称: 4-O-Carboxymethylascochlorin
• 英文别名: 2-[2-chloro-4-formyl-5-hydroxy-3-methyl-6-[(2E,4E)-3-methyl-5-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-2,4-dienyl]phenoxy]acetic acid
• CAS: 84435-25-6
• 化学式: C₂₅H₃₁ClO₆
• 分子量: 462.971
• InChiKey: YRRAKQFQGINEPT-KPKJWKMQSA-N

物化性质

• 沸点：
  611.2±55.0 °C(Predicted)
• 密度：
  1.236±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲醇 、 4-O-羧甲基壳二孢氯素 生成 4-O-carboxymethylascochlorin dimethylacetal
  参考文献：
  名称：

  Method for preparing novel transcription factors and use

  摘要：

  本发明的目的是开发新的化合物，用于治疗综合征X、癌症、黏液水肿、血管慢性炎症等疾病，并且预防/治疗由气球或支架扩张引起的动脉再狭窄，通过抑制自体细胞或组织的排斥反应促进再生医学，并提供制备这些化合物的方法。发现通过对ascochlorin及其类似物中2-位置的羟基进行酰化，并在碱性催化剂存在下将醇键合到醛基上，可以实现这一目标，从而获得新的缩醛衍生物。

  公开号：

  US20070054966A1

文献信息

• NOVEL TRANSCRIPTIONAL FACTOR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  申请人：NRL Pharma, Inc.

  公开号：EP1616856B1

  公开（公告）日：2011-06-22
• TARGETED TREATMENT OF AUTISM SPECTRUM DISORDER AND OTHER NEUROLOGICAL OR PSYCHIATRIC DISORDERS
  申请人：Tufts Medical Center, Inc.

  公开号：US20210228531A1

  公开（公告）日：2021-07-29

  Disclosed are methods of treating autism spectrum disorder (ASD) by administering a therapeutically effective amount of an isoprenoid antibiotic to subjects identified with a splicing defect in an ASD associated gene. The method of treating a subject with a neurological disease is carried out by identifying the subject comprising a splicing defect in an autism spectrum disorder (ASD)-associated gene, the target gene being characterized as having an hnRNP L binding site. The subject is treated by administering a spliceopathy rescue agent to repair the splicing defect. Also disclosed are methods of upregulating hnRNP L and hnRNP L targets by administering a therapeutically effective amount of an isoprenoid antibiotic. Methods of screening compounds for use in treating autism spectrum disorder (ASD) are also described.
• COMPOUNDS AND METHODS FOR THE TREATMENT OF AUTISM SPECTRUM DISORDER AND OTHER NEUROLOGICAL OR PSYCHIATRIC DISORDERS
  申请人：Tufts Medical Center, Inc.

  公开号：US20210236438A1

  公开（公告）日：2021-08-05

  Disclosed are methods of treating autism spectrum disorder (ASD) by administering a therapeutically effective amount of an isoprenoid antibiotic. Also disclosed are methods of modulating (either upregulation or downregulation) hnRNP L and hnRNP L targets by administering a therapeutically effective amount of an isoprenoid antibiotic. Methods of screening compounds for use in treating autism spectrum disorder (ASD) are also described.
• US7629471B2
  申请人：——

  公开号：US7629471B2

  公开（公告）日：2009-12-08
• Method for preparing novel transcription factors and use
  申请人：Kitahara Takeshi

  公开号：US20070054966A1

  公开（公告）日：2007-03-08

  The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.

  本发明的目的是开发新的化合物，用于治疗综合征X、癌症、黏液水肿、血管慢性炎症等疾病，并且预防/治疗由气球或支架扩张引起的动脉再狭窄，通过抑制自体细胞或组织的排斥反应促进再生医学，并提供制备这些化合物的方法。发现通过对ascochlorin及其类似物中2-位置的羟基进行酰化，并在碱性催化剂存在下将醇键合到醛基上，可以实现这一目标，从而获得新的缩醛衍生物。