5-bromo-2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one | 1229017-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-bromo-2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one
• 英文别名: 5-bromo-6-phenyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-on；5-bromo-6-phenyl-2-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one；5-bromo-2-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-4-phenyl-1H-pyrimidin-6-one
• CAS: 1229017-14-4
• 化学式: C₂₃H₂₅BrN₄O₄S
• 分子量: 533.446
• InChiKey: YHWLMQGTLBKBSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  99.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one 在 吡啶 、 溴 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以68%的产率得到5-bromo-2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one
  参考文献：
  名称：

  Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

  摘要：

  The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.062

文献信息

• PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
  申请人：Topharman Shanghai Co., Ltd.

  公开号：EP2383262B1

  公开（公告）日：2016-07-06
• US8871777B2
  申请人：——

  公开号：US8871777B2

  公开（公告）日：2014-10-28