1H-anthra[1,2-d][1,2,3]triazole | 227-68-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1H-anthra[1,2-d][1,2,3]triazole
• 英文别名: 1H-Anthra[1,2-d][1,2,3]triazol；Aza-anthrapyrazole；2H-naphtho[2,3-e]benzotriazole
• CAS: 227-68-9
• 化学式: C₁₄H₉N₃
• 分子量: 219.246
• InChiKey: MDNREWZRMPTNNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 sodium nitrite 作用下， 生成 1H-anthra[1,2-d][1,2,3]triazole
  参考文献：
  名称：

  Martin; van Hove, Bulletin des Societes Chimiques Belges, 1957, vol. 66, p. 438,448, 449

  摘要：

  DOI：

文献信息

• Aza-benzothiopyranoindazoles with antitumor activity
  申请人：——

  公开号：US20030225069A1

  公开（公告）日：2003-12-04

  The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and methods of treating tumors and cancer in mammals with the compounds of the present invention are also disclosed.

  本发明涉及一组具有抗肿瘤活性的氮杂蒽吡唑化合物，以及其制备方法。本发明还公开了含有氮杂蒽吡唑化合物的组合物，以及使用本发明的化合物治疗哺乳动物的肿瘤和癌症的方法。
• Fluorochromes for organelle tracing and multi-color imaging
  申请人：Patton Wayne Forrest

  公开号：US20100062429A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和试剂盒，用于鉴定感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，用于确定细胞器的位置、数量，甚至用于区分感兴趣的细胞中的细胞器。
• Novel fluorochromes for organelle tracing and multi-color imaging
  申请人：Pande Praveen

  公开号：US20100062460A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和工具包，用于识别感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，以识别感兴趣细胞中细胞器的位置、位置或数量，甚至用于区分细胞器。
• 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments
  申请人：Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG

  公开号：EP3064207A1

  公开（公告）日：2016-09-07

  The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula I or pharmaceutically acceptable salts or propharmacons thereof for use as BCRP inhibitors, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant σp greater than 0.23. For corresponding compounds, surprisingly a particularly high inhibitory activity against BCRP has been discovered which can be exploited for supressing the multidrug resistance modulator BCRP, thus providing an improvement in efficacy of BCRP affected drugs. This has useful implications for cancer and HIV treatment.

  本发明涉及通式 I 的 5-氨基-3-苯基氨基-6-苯基吡唑并[3,4-d]嘧啶衍生物 或其药学上可接受的盐或原药，用作 BCRP 抑制剂，其中至少一个苯基 A 和 B 中的至少一个氢原子被取代基 RH 取代，该取代基的哈米特常数 σp 大于 0.23。对于相应的化合物，令人惊讶的是发现了一种对 BCRP 具有特别高抑制活性的化合物，这种化合物可用于抑制多药耐药性调节剂 BCRP，从而提高受 BCRP 影响的药物的疗效。这对癌症和艾滋病毒的治疗具有重要意义。
• Breast cancer resistance protein (BCRP) and the DNA which encode it
  申请人：University of Maryland Baltimore

  公开号：US20030036645A1

  公开（公告）日：2003-02-20

  The Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.

  介绍了乳腺癌抗药性蛋白以及编码该蛋白的 cDNA。研究发现，这种蛋白质能使人对癌症化疗药物产生抗药性。