4,4-Bis-(4-fluorophenyl)-butyramid | 51787-97-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4-Bis-(4-fluorophenyl)-butyramid
• 英文别名: 4-Fluoro-I(3)-(4-fluorophenyl)benzenebutanamide；4,4-bis(4-fluorophenyl)butanamide
• CAS: 51787-97-4
• 化学式: C₁₆H₁₅F₂NO
• 分子量: 275.298
• InChiKey: HKABJZROZCPIKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4-bis(4-fluorophenyl)but-3-enoic acid 生成 4,4-Bis-(4-fluorophenyl)-butyramid
  参考文献：
  名称：

  Neurotropic and psychotropic agents. LXVII. 1-[4,4-Bis(4-fluorophenyl)butyl]-4-hydroxy-4-(3-trifluoromethyl-4-chlorophenyl)piperidine and related compounds: New synthetic approaches

  摘要：

  DOI：

  10.1135/cccc19733879

文献信息

• [EN] SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS<br/>[FR] AMIDES DE DIARYLALKYLE SUBSTITUES EN TANT QU'ANTAGONISTES DE CANAUX CALCIQUES
  申请人：WARNER-LAMBERT COMPANY

  公开号：WO1999055688A1

  公开（公告）日：1999-11-04

  (EN) The present invention provides compounds that block calcium channels and have Formula (I). The present invention also provides pharmaceutical compositions containing the compounds of Formula (I) and methods of using them to treat stroke, cerebral ischemia, head trauma, and epilepsy.(FR) L'invention concerne des composés de formule (I) inhibant les canaux calciques. L'invention concerne également des compositions pharmaceutiques renfermant les composés de formule (I) et leurs procédés d'utilisation pour traiter les accidents cérébrovasculaires, l'ischémie cérébrale, des traumatismes crâniens et l'épilepsie.

  本发明提供了一种阻断钙通道的化合物，其具有公式（I）。本发明还提供了含有公式（I）化合物的药物组合物以及使用它们治疗中风、脑缺血、头部创伤和癫痫的方法。
• Anticonvulsant and central nervous system-depressing bis (fluorophenyl) alkylamides and their uses
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US20030199589A1

  公开（公告）日：2003-10-23

  Bis(Fluorophenyl)alkylamides have been chemically synthesized which possess beneficial pharmacological properties (e.g., anticonvulsant activity) useful for the treatment of neurological diseases or disorders, such as, for example, epilepsy, convulsions, and seizure disorders. The preferred compounds of the invention also cause little sedation and have high therapeutic and protective indices in animal models of epilepsy. These compounds further possess long pharmacologic half-lives, which, in practical clinical therapeutic application, should translate into once-a-day dosing, of great benefit to patients suffering from these diseases and/or disorders. These compounds may also be of further clinical utility in the treatment of other diseases and disorders of the central and peripheral nervous systems, or diseases or disorders affected by them, including, but not limited to, spasticity, skeletal muscle spasms and pain, restless leg syndrome, anxiety and stress, and bipolar disorder.

  已经合成了具有有益药理特性（例如，抗惊厥活性）的双（氟苯基）烷基酰胺类化合物，可用于治疗神经系统疾病或障碍，例如癫痫、抽搐和癫痫性疾病。本发明的优选化合物还会引起较少的镇静作用，并在癫痫动物模型中具有高的治疗和保护指数。这些化合物还具有长的药理学半衰期，在实际的临床治疗应用中，应该可以转化为一天一次的剂量，对于患有这些疾病和/或障碍的患者非常有益。这些化合物还可能在治疗中枢和外周神经系统的其他疾病和障碍，或受其影响的疾病和障碍方面具有进一步的临床实用性，包括但不限于痉挛、骨骼肌痉挛和疼痛、不宁腿综合症、焦虑和压力以及双相障碍。
• Pharmaceutical composition containing gabapentin or pregabalin and N-type calcium channel antagonist
  申请人：Iwayama Satoshi

  公开号：US20050009814A1

  公开（公告）日：2005-01-13

  The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

  本发明涉及一种用于预防/治疗疼痛的药物组合物，包括加巴喷丁或普瑞巴林或其药学上可接受的盐和N型钙通道拮抗剂或其药学上可接受的盐，例如具有以下结构的化合物。
• MEDICINAL COMPOSITIONS CONTAINING GABAPENTIN OR PREGABALIN AND N-TYPE CALCIUM CHANNEL ANTAGONIST
  申请人：Ajinomoto Co., Inc.

  公开号：EP1481673A1

  公开（公告）日：2004-12-01

  The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

  本发明涉及一种用于预防/治疗疼痛的药物组合物，它包括加巴喷丁或普瑞巴林或其药学上可接受的盐类与 N 型钙通道拮抗剂或其药学上可接受的盐类的组合，例如具有以下结构的化合物。
• Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1640359A2

  公开（公告）日：2006-03-29

  Bis(Fluorophenyl)alkylamides have been chemically synthesized which possess beneficial pharmacological properties (e.g., anticonvulsant activity) useful for the treatment of neurological disease or disorders, such as, for example, epilepsy, convulsions, and seizure disorders. The preferred compounds of the invention also cause little sedation and have high therapeutic and protective indices in animal models of epilepsy. These compounds further possess long pharmacologic half-lives, which, in practical clinical therapeutic application, should translate into once-a-day dosing, of great benefit to patients suffering from these diseases and/or disorders. These compounds may also be of further clinical utility in the treatment of other diseases and disorders of the central and peripheral nervous systems, or diseases or disorders affected by them, including, but not limited to, spasticity, skeletal muscle spasms and pain, restless leg syndrome, anxiety and stress, and bipolar disorder.

  双(氟苯基)烷基酰胺已被化学合成，具有有益的药理特性（如抗惊厥活性），可用于治疗神经系统疾病或紊乱，如癫痫、抽搐和癫痫发作紊乱等。本发明的优选化合物也几乎不会引起镇静，在癫痫动物模型中具有较高的治疗和保护指数。这些化合物还具有较长的药理半衰期，在实际临床治疗应用中，可实现一天一次给药，对这些疾病和/或失调患者大有裨益。这些化合物在治疗中枢和周围神经系统的其他疾病和失调，或受其影响的疾病或失调，包括但不限于痉挛、骨骼肌痉挛和疼痛、不安腿综合征、焦虑和压力，以及躁郁症等方面，也可能具有进一步的临床效用。