3-hydroxy-benzidine | 3366-54-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-benzidine
• 英文别名: 3-Hydroxy-benzidin；4.4'-Diamino-3-oxy-diphenyl；4,4'-diamino-3-hydroxybiphenyl；3-Hydroxybenzidine；2-amino-5-(4-aminophenyl)phenol
• CAS: 3366-54-9
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: CSXIQWQKAJYFAL-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C
• 沸点：
  399.6±37.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-ethoxy-benzidine 在 sodium hydroxide 作用下， 250.0~260.0 ℃ 、5.88 MPa 条件下， 生成 3-hydroxy-benzidine
  参考文献：
  名称：

  DE727869

  摘要：

  公开号：

文献信息

• Metabolism of Two Aromatic Amines in the Dog
  作者：L. BRADSHAW、D. B. CLAYSON

  DOI：10.1038/176974a0

  日期：1955.11

  CLAYSON1 has suggested that aromatic amines are carcinogenic by virtue of their transformation in the animal body into orthohydroxyamines. Walpole, Williams and Roberts2 have shown that 4-amino-diphenyl is a potent inducer of bladder tumours in the dog, and Spitz (quoted by Walpole et al.2) has obtained bladder tumours in this species with benzidine. The purpose of this communication is to show that these aromatic amines are in fact converted into orthohydroxyamine derivatives by the dog.

  CLAYSON1 认为芳香胺具有致癌性，因为它们在动物体内转化为邻羟胺。 Walpole、Williams 和 Roberts2 已证明 4-氨基联苯是狗膀胱肿瘤的有效诱导剂，而 Spitz（Walpole 等人引用2）已用联苯胺在该物种中获得了膀胱肿瘤。本次交流的目的是表明这些芳香胺实际上被狗转化为邻羟胺衍生物。
• Antioxidant and bisaminophenol derivative
  申请人：Shiraki Yasushi

  公开号：US20060208227A1

  公开（公告）日：2006-09-21

  The present invention provides antioxidants made of an aromatic hydroxyamine derivative having a structure represented by the general formula (I): wherein R 1 , R 2 and R 3 are each independently a hydrogen atom or an alkyl group having 1 to 20 carbon atoms; X is a hydrogen atom or an OH group; Y is a hydrogen atom or an NHR 1 group; A is a direct bond, —O—, —NH—, —SO 2 —, —CH 2 — or —C(CH 3 ) 2 —, and when an OH group and an NHR 1 group are introduced to a unilateral benzene ring, these groups are respectively bonded to adjacent positions of the benzene ring; and n is 0 or 1 with the proviso that when n is 0, R 1 is not a hydrogen atom, as well as bisaminophenol derivatives represented by the above general formula (I) wherein n is 1; R 2 and R 3 are each a hydrogen atom; X is an OH group; Y is an NHR 1 group; A is —C(CH 3 ) 2 —; and R 1 is isopropyl, isobutyl or isohexyl. The aromatic hydroxyamine derivatives having a structure represented by the general formula (I), in particular, the bisaminophenol derivatives as novel substances, exhibit an excellent oxidation-inhibiting property, and are usable as antioxidants or polymerization inhibitors.

  本发明提供一种抗氧化剂，其由一种芳香族羟胺衍生物制成，其结构由通式（I）表示： 其中，R1、R2和R3分别独立地为氢原子或具有1到20个碳原子的烷基；X为氢原子或OH基团；Y为氢原子或NHR1基团；A为直接键，-O-，-NH-，-SO2-，-CH2-或-C(CH3)2-，当OH基团和NHR1基团被引入单侧苯环时，这些基团分别与苯环的相邻位置键合；n为0或1，但当n为0时，R1不是氢原子，以及由上述通式（I）表示的双氨基酚衍生物，其中n为1；R2和R3均为氢原子；X为OH基团；Y为NHR1基团；A为-C(CH3)2-；R1为异丙基、异丁基或异己基。具有通式（I）表示的芳香族羟胺衍生物，特别是作为新物质的双氨基酚衍生物，表现出优异的抗氧化性能，并可用作抗氧化剂或聚合物抑制剂。
• ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE
  申请人：SHIRAKI Yasushi

  公开号：US20080161608A1

  公开（公告）日：2008-07-03

  The present invention provides antioxidants made of an aromatic hydroxyamine derivative having a structure represented by the general formula (I): wherein R 1 , R 2 and R 3 are each independently a hydrogen atom or an alkyl group having 1 to 20 carbon atoms; X is a hydrogen atom or an OH group; Y is a hydrogen atom or an NHR 1 group; A is a direct bond, —O—, —NH—, —SO 2 —, —CH 2 — or —C(CH 3 ) 2 —, and when an OH group and an NHR 1 group are introduced to a unilateral benzene ring, these groups are respectively bonded to adjacent positions of the benzene ring; and n is 0 or 1 with the proviso that when n is 0, R 1 is not a hydrogen atom, as well as bisaminophenol derivatives represented by the above general formula (I) wherein n is 1; R 2 and R 3 are each a hydrogen atom; X is an OH group; Y is an NHR 1 group; A is —C(CH 3 ) 2 —; and R 1 is isopropyl, isobutyl or isohexyl. The aromatic hydroxyamine derivatives having a structure represented by the general formula (I), in particular, the bisaminophenol derivatives as novel substances, exhibit an excellent oxidation-inhibiting property, and are usable as antioxidants or polymerization inhibitors.

  本发明提供了一种芳香族羟胺衍生物制备的抗氧化剂，其结构由通式（I）表示：其中，R1、R2和R3各自独立地是氢原子或具有1到20个碳原子的烷基基团；X是氢原子或羟基（OH）基团；Y是氢原子或NHR1基团；A是直接键、—O—、—NH—、—SO2—、—CH2—或—C（CH3）2—，当在一个单侧苯环上引入OH基团和NHR1基团时，这些基团分别与苯环的相邻位置结合；n为0或1，但当n为0时，R1不是氢原子。此外，本发明还提供了通式（I）所表示的双氨基酚衍生物，其中n为1；R2和R3均为氢原子；X为羟基（OH）基团；Y为NHR1基团；A为—C（CH3）2—；而R1为异丙基、异丁基或异己基。具有通式（I）所表示的芳香族羟胺衍生物，尤其是作为新化合物的双氨基酚衍生物，表现出优异的抗氧化性能，可用作抗氧化剂或聚合抑制剂。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• Photosensitive resin composition
  申请人：HITACHI CHEMICAL CO., LTD.

  公开号：EP0642057A1

  公开（公告）日：1995-03-08

  There are disclosed a photosensitive resin composition which comprises (A) a polyamic acid having recurring units represented by the formula (I):    wherein R¹ represents and R²    represents a divalent organic group, and (B) an acryl compound having an amino group,    and also a photosensitive resin composition for an i-line stepper which further comprises a photoinitiator in addition to the photosensitive resin composition.

  公开了一种光敏树脂组合物，它包括 (A) 具有由式(I)表示的重复单元的聚酰胺酸： 其中 R¹ 代表 和 R² 代表二价有机基团，以及 (B) 具有氨基的丙烯酸化合物、 以及一种用于 i 线步进机的光敏树脂组合物，该组合物除光敏树脂组合物外，还包括一种光引发剂。