N-(3-fluorophenyl)-4-(4-pyrrolidin-1-ylphenyl)-1,3-thiazol-2-amine | 700803-54-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(3-fluorophenyl)-4-(4-pyrrolidin-1-ylphenyl)-1,3-thiazol-2-amine
• CAS: 700803-54-9
• 化学式: C₁₉H₁₈FN₃S
• 分子量: 339.436
• InChiKey: JZHUAEMEPCQAFH-UHFFFAOYSA-N

物化性质

• 沸点：
  518.1±60.0 °C(predicted)
• 密度：
  1.294±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(3-氟苯基)-2-硫脲 、 2-溴-4’-(1-吡咯烷基)苯乙酮 以 乙醇 为溶剂， 反应 0.5h， 以40%的产率得到N-(3-fluorophenyl)-4-(4-pyrrolidin-1-ylphenyl)-1,3-thiazol-2-amine
  参考文献：
  名称：

  Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA

  摘要：

  Privileged structure-based libraries have been shown to provide high affinity lead compounds for a variety of important biological targets. The present study describes the synthesis and screening of a 2-aminothiazole based compound library to determine their utility as antimicrobials, focusing on MRSA. Several of the compounds in this series demonstrated improved antimicrobial activity as compared to ceftriaxone (CTX), a beta-lactam antibiotic. The most potent compound (21) had MICs in the range of 24 mu g/ml across a panel of Staphylococcus aureus strains. In addition, trifluoromethoxy substituted aminothiazoles and aminobenzothiazoles were found to be potent antimicrobials with MICs of 2-16 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.095

文献信息

• Compounds and Uses Thereof in Modulating Amyloid Beta
  申请人：Cheng Soan

  公开号：US20070260058A1

  公开（公告）日：2007-11-08

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新的化合物、组合物和试剂盒。还提供了调节Aβ水平的方法以及治疗与异常Aβ水平相关的疾病的方法。
• COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA
  申请人：Cheng Soan

  公开号：US20100324032A1

  公开（公告）日：2010-12-23

  Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.

  本发明提供了新型化合物、组合物和试剂盒。还提供了调节Aβ水平的方法和治疗与异常Aβ水平相关的疾病的方法。
• US7244739B2
  申请人：——

  公开号：US7244739B2

  公开（公告）日：2007-07-17
• US7781442B2
  申请人：——

  公开号：US7781442B2

  公开（公告）日：2010-08-24
• US8017629B2
  申请人：——

  公开号：US8017629B2

  公开（公告）日：2011-09-13