1-ethyl-2-carboxy-pyridinium betaine | 85574-20-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-ethyl-2-carboxy-pyridinium betaine
• 英文别名: 1-Aethyl-2-carboxy-pyridinium-betain；1-Ethylpyridin-1-ium-2-carboxylate
• CAS: 85574-20-5
• 化学式: C₈H₉NO₂
• 分子量: 151.165
• InChiKey: BBQLCWQSKJTZCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-ethyl-2-carboxy-pyridinium betaine 在 sulfur 作用下， 以 xylene 为溶剂， 反应 2.0h， 以60%的产率得到1-Ethyl-pyridthion-(2)
  参考文献：
  名称：

  The Conversion of Pyridinium-2-carboxylates into 2-Thioxo-1,2-dihydropyridines (Pyridine-2-thiones)

  摘要：

  DOI：

  10.1055/s-1983-30261
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 水 、 silver(l) oxide 作用下， 生成 1-ethyl-2-carboxy-pyridinium betaine
  参考文献：
  名称：

  Meyer,H., Monatshefte fur Chemie, 1894, vol. 15, p. 173

  摘要：

  DOI：

文献信息

• 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0090366A1

  公开（公告）日：1983-10-05

  A compound of the formula: in which R1 is hydroxy, a protected hydroxy group or lower alkoxy, R2 is carboxy or a protected carboxy group and R3 is aryl having suitable substituent(s), pyridyl which may have suitable substituent(s) or heterocyclic group containing 3 to 5 hetero atoms which may have suitable substituent(s), and pharmaceutically acceptable salts thereof, and also processes for their preparation and pharmaceutical compositions containing them in admixture with pharmaceutically acceptable carriers.

  式的化合物： 其中 R1 是羟基、受保护的羟基或低级烷氧基、 R2 是羧基或受保护的羧基，以及 R3 是具有合适取代基的芳基、可具有合适取代基的吡啶基或可具有合适取代基的含 3 至 5 个杂原子的杂环基团，以及它们的药学上可接受的盐，以及它们的制备方法和含有它们并与药学上可接受的载体混合的药物组合物。
• New cephem compounds, processes for preparation thereof and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0133678A2

  公开（公告）日：1985-03-06

  New cephem compound of the formula : wherein R' is amino or acylamino, R2 is hydrogen, aryl which may have suitable substituent(s), a heterocyclic group which may have suitable substituent(s) or cyano, and R3 is carboxy or protected carboxy, and pharmaceutically acceptable salt thereof, processes for its preparation and pharmaceutical compositions comprising them in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to intermediate compounds of the formula and their preparation and intermediate compounds of the formula

  式中R'为氨基或酰氨基，R2为氢、可具有适当取代基的芳基、可具有适当取代基的杂环基团或氰基，R3为羧基或受保护羧基的新头孢化合物及其药学上可接受的盐、其制备工艺以及由它们与药学上可接受的、基本上无毒的载体或赋形剂组成的药物组合物。 本发明还涉及式的中间体化合物及其制备方法和式的中间体化合物
• Cephem compounds and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0145906A2

  公开（公告）日：1985-06-26

  New cephem compounds of the formula: wherein R' is amino or protected amino, R' is aryl which may have suitable substituent(s), a heterocyclic group which may have suitable substituent(s), cyano, hydrogen or tri(lower)alkylsilyl, R' is carboxy or protected carboxy, and A is -CH=CH- or -C≡C-, and pharmaceutically acceptable saltthereof, processes for their preparation and pharmaceutical compositions containing them in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to intermediates of the formula and processes for their preparation.

  新的 Cephem 化合物，其式如下 式中 R' 是氨基或保护氨基、 R'是芳基（可具有合适的取代基）、杂环基（可具有合适的取代基）、氰基、氢或三（低）烷基硅基、 R' 是羧基或受保护的羧基，以及 A是-CH=CH-或-C≡C-，以及它们的药学上可接受的盐、它们的制备工艺和含有它们与药学上可接受的、基本上无毒的载体或赋形剂的药物组合物。本发明还涉及式 及其制备工艺。
• New starting compounds for cephem compounds and processes for their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0268307A2

  公开（公告）日：1988-05-25

  A compound of the formula : vherein R11 is (C1-C6)alkanoyl or a group of the formula : R5 is amino or protected amino, and R6 is hydrogen or an organic group which may have suitable substituent(s), R3 is carboxy or protected carboxy, and Y2 is (C1-C6)alkanesulfonyloxy, and a salt thereof and processes for the preparation thereof.

  式中 R11 为(C1-C6)烷酰基或式中 R5 为氨基或受保护氨基，R6 为氢或可具有适当取代基的有机基团，R3 为羧基或受保护羧基，Y2 为(C1-C6)烷磺酰氧基的化合物及其盐和制备方法。
• Turnau, Monatshefte fur Chemie, 1905, vol. 26, p. 559
  作者：Turnau

  DOI：——

  日期：——