2-{[(2-morpholin-4-ylethyl)carbamoyl]amino}-1,3-benzothiazol-6-yl 2,6-dichlorobenzenesulfonate | 929960-68-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{[(2-morpholin-4-ylethyl)carbamoyl]amino}-1,3-benzothiazol-6-yl 2,6-dichlorobenzenesulfonate
• 英文别名: [2-(2-morpholin-4-ylethylcarbamoylamino)-1,3-benzothiazol-6-yl] 2,6-dichlorobenzenesulfonate
• CAS: 929960-68-9
• 化学式: C₂₀H₂₀Cl₂N₄O₅S₂
• 分子量: 531.441
• InChiKey: WERHTGPMOZFUMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,6-二氯苯磺酰氯 、 1-(6-hydroxy-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 23.0h， 生成 2-{[(2-morpholin-4-ylethyl)carbamoyl]amino}-1,3-benzothiazol-6-yl 2,6-dichlorobenzenesulfonate
  参考文献：
  名称：

  Novel Benzimidazole and Benzothiazole Derivatives, Method for Preparing Same, Use Thereof as Drugs, Pharmaceutical Compositions and Novel Use Especially as c-MET Inhibitors

  摘要：

  本发明涉及公式（I）的苯并咪唑和苯并噻唑化合物的制备方法，包括这些化合物的制药组合物，以及包括这些化合物的治疗方法的管理方法。

  公开号：

  US20080194555A1

文献信息

• Benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as c-MET inhibitors
  申请人：Aventis Pharma S.A.

  公开号：US08110571B2

  公开（公告）日：2012-02-07

  This invention relates to benzimidazole and benzothiazole compounds of formula (I) to methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.

  本发明涉及化合物(I)的苯并咪唑和苯并噻唑，以及制备此类化合物的方法，包含此类化合物的药物组成物，以及包含这类化合物的治疗方法。
• DERIVES DE BENZIMIDAZOLES ET BENZOTHIAZOLES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASES NOTAMMENT DE MET
  申请人：Aventis Pharma S.A.

  公开号：EP1934187A1

  公开（公告）日：2008-06-25
• US8110571B2
  申请人：——

  公开号：US8110571B2

  公开（公告）日：2012-02-07
• [EN] NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS<br/>[FR] DERIVES DE BENZIMIDAZOLES ET BENZOTHIAZOLES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE KINASES NOTAMMENT DE MET
  申请人：AVENTIS PHARMA SA

  公开号：WO2007036630A1

  公开（公告）日：2007-04-05

  [EN] The invention concerns novel products of formula (I), wherein: A represents NH or S; R1, R2 and R3 represent H, NH2, Hal or Alk, one at least of R1, R2 and R3 being other than hydrogen; R represents in particular: cycloalkyl, alkyl, alkoxy or NR4R5, R4 representing H or Alk and R5 representing cycloalkyl or alkyl optionally substituted by hydroxyl, alkoxy, heteroaryl, heterocycloalkyl, NR6R7, phenyl, phenyl-NR6R7 and CONR6R7, R6 and R7 representing H or Alk or phenyl and R6 and R7 may form together with H a cyclic radical; R4 and R5 may also form together with N a cyclic radical; all the above heterocycloalkyl, heteroaryl and phenyl radicals being optionally substituted, said products being in all the isomeric forms and their salts, as medicines in particular as Met inhibitors.
  [FR] L'invention concerne les nouveaux produits de formule (I) à titre de médicaments notamment comme inhibiteurs de protéins Limases telles que Met.
• Novel Benzimidazole and Benzothiazole Derivatives, Method for Preparing Same, Use Thereof as Drugs, Pharmaceutical Compositions and Novel Use Especially as c-MET Inhibitors
  申请人：NEMECEK Conception

  公开号：US20080194555A1

  公开（公告）日：2008-08-14

  This invention relates to benzimidazole and benzothiazole compounds of formula (I) to methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.

  本发明涉及公式（I）的苯并咪唑和苯并噻唑化合物的制备方法，包括这些化合物的制药组合物，以及包括这些化合物的治疗方法的管理方法。