2-(1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal | 1258548-47-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-(1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal
• 英文别名: 2-[(3R)-1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-2-methylpropanal
• CAS: 1258548-47-8
• 化学式: C₁₄H₁₄FNO₃
• 分子量: 263.268
• InChiKey: UGQUUNHVKVDWTA-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-氟苯基)-1H-吡咯-2,5-二酮 、 异丁醛 在 N-[(1R,2R)-2-氨基环己基]-N'-[3,5-双(三氟甲基)苯基]硫脲 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以97%的产率得到2-(1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal
  参考文献：
  名称：

  Chiral primary amine thiourea promoted highly enantioselective Michael reactions of isobutylaldehyde with maleimides

  摘要：

  Chiral primary amine thiourea catalysts were first successfully applied to promote Michael addition of isobutyraldehyde to maleimides. A variety of N-aryl and N-aliphatic maleimides provided Michael adducts in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) with 5 mol % catalyst. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.09.044

文献信息

• Chiral primary amine thiourea promoted highly enantioselective Michael reactions of isobutylaldehyde with maleimides
  作者：Jian-Fei Bai、Lin Peng、Liang-liang Wang、Li-Xin Wang、Xiao-Ying Xu

  DOI：10.1016/j.tet.2010.09.044

  日期：2010.11

  Chiral primary amine thiourea catalysts were first successfully applied to promote Michael addition of isobutyraldehyde to maleimides. A variety of N-aryl and N-aliphatic maleimides provided Michael adducts in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) with 5 mol % catalyst. (C) 2010 Elsevier Ltd. All rights reserved.