N-propargyl-N-methyl-α-phenyl(n-propyl)amine | 127980-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-propargyl-N-methyl-α-phenyl(n-propyl)amine
• 英文别名: N-methyl-1-phenyl-N-prop-2-ynylpropan-1-amine
• CAS: 127980-64-7
• 化学式: C₁₃H₁₇N
• 分子量: 187.285
• InChiKey: JFDNFQJIZGPFGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  、 3-溴丙炔 在 bis(acetylacetonato)palladium(II) 、 三苯基膦 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以70%的产率得到N-propargyl-N-methyl-α-phenyl(n-propyl)amine
  参考文献：
  名称：

  Synthesis of unsaturated tertiary amines and ?-allyl substituted ketones from azomethines using metal complex catalysts

  摘要：

  DOI：

  10.1007/bf00963019

文献信息

• Transdermal composition containing selegiline
  申请人：CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

  公开号：EP0509761A1

  公开（公告）日：1992-10-21

  The invention concerns an anhydrous transdermal preparation comprising in a 20-100% lyotropic liquid crystalline arrangement:    5-15 w.% of optically active or racemic N-methyl-N-(phenyl-2-propyl)-2-propynylamine or N-methyl-N-(1-(4-fluoro-phenyl)-2-propyl)-2-propynylamine or their therapeutically acceptable salts,    40-70 w.% of liquid polyoxyethyleneglycol,    10-20 w.% of solid polyoxyethyleneglycol,    2-30 w.% of a nonionic surface active agent,    2-20 w.% of propyleneglycol, if desired 0.5-2 w.% of a polymer the a value of which is > 0.6, and if desired other auxiliary agents.

  本发明涉及一种无水透皮制剂，该制剂由 20-100% 的冻融液晶排列组成： 5-15%光学活性的或外消旋的N-甲基-N-(苯基-2-丙基)-2-丙炔胺或N-甲基-N-(1-(4-氟苯基)-2-丙基)-2-丙炔胺或它们的治疗上可接受的盐、 40-70% 的液态聚氧乙烯乙二醇、 10-20 重量百分比的固体聚氧乙烯乙二醇、 2-30 重量百分比的非离子表面活性剂、 2-20 重量百分比的丙二醇、 如果需要，0.5-2 重量百分比的聚合物（其 a 值大于 0.6），以及其他辅助剂。
• Device and method for delivering an ingestible medicament into the gastrointestinal tract of a user
  申请人：VIBRANT LTD.

  公开号：US10814113B2

  公开（公告）日：2020-10-27

  Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitator disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

  向使用者的胃肠道输送可食用药片的设备和方法。根据本发明，一种设备包括一个振动可摄取胶囊和一个中空的药剂室外壳。振动胶囊包括外壳、置于外壳内的振动搅拌器、电源和控制元件。中空药室外壳与胶囊外壳相连，并包括至少一个孔。药室外壳的中空部分被配置为放置药片。孔的尺寸可使周围环境和中空的流体相通。
• Device and method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user
  申请人：VIBRANT LTD.

  公开号：US11020018B2

  公开（公告）日：2021-06-01

  A device and a method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user. The device includes a vibrating ingestible capsule attached to a medicament delivery compartment. The medicament delivery compartment includes a housing including a portal, a medicament reservoir, a reservoir biasing mechanism applying pressure to the reservoir, a resilient conduit extending from the reservoir to the portal, and a valve including a weight and a spring adapted, when closed, to bias the weight against the conduit so as to block flow therethrough, and, when open, to remove the weight from the conduit to allow fluid to flow through the conduit. When the vibrating agitator is in the vibration mode of operation, vibrations exerted thereby are applied to the valve biasing mechanism and periodically transition the valve between the closed operative orientation and the open operative orientation.

  一种将可流动的可食用药物送入使用者胃肠道的装置和方法。该装置包括一个振动可摄取胶囊，胶囊与一个药物输送舱相连。给药舱包括一个壳体，壳体上有一个入口、一个储药箱、一个对储药箱施加压力的储药箱偏压机构、一个从储药箱延伸到入口的弹性导管，以及一个阀门，阀门上有一个砝码和一个弹簧，当阀门关闭时，砝码偏向导管以阻挡流体通过；当阀门打开时，砝码从导管上移开以允许流体通过导管。当振动搅拌器处于振动工作模式时，由此产生的振动作用于阀门偏置机构，并周期性地使阀门在关闭工作方向和打开工作方向之间转换。
• Betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject
  申请人：INTRABIO LTD

  公开号：US11083718B2

  公开（公告）日：2021-08-10

  A first aspect of the invention relates to betahistine, or a pharmaceutically acceptable salt thereof, and a monoamine oxidase inhibitor, for use in the treatment or prevention of one or more symptoms of vertigo in a subject. A second aspect of the invention relates to a method of treating or preventing one or more symptoms of vertigo in a subject, said method comprising administering to the subject (i) betahistine, or a pharmaceutically acceptable salt thereof, and (ii) a monoamine oxidase inhibitor.

  本发明的第一个方面涉及用于治疗或预防受试者一种或多种眩晕症状的倍他司汀或其药学上可接受的盐和单胺氧化酶抑制剂。本发明的第二个方面涉及一种治疗或预防受试者的一种或多种眩晕症状的方法，所述方法包括向受试者施用(i)倍他司汀或其药学上可接受的盐，以及(ii)单胺氧化酶抑制剂。
• IBRAGIMOV, A. G.;MINSKER, D. L.;MOROZOV, A. B.;GALKIN, E. M.;DZHEMILEV, U+, IZV. AN CCCP. CEP. XIM.,(1990) N, S. 155-160
  作者：IBRAGIMOV, A. G.、MINSKER, D. L.、MOROZOV, A. B.、GALKIN, E. M.、DZHEMILEV, U+

  DOI：——

  日期：——