6-(1-fluoroethyl)-5-iodo-4-(2-phenylethylamino)pyrimidine | 245651-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(1-fluoroethyl)-5-iodo-4-(2-phenylethylamino)pyrimidine
• 英文别名: 6-(1-fluoroethyl)-5-iodo-N-(2-phenylethyl)pyrimidin-4-amine
• CAS: 245651-53-0
• 化学式: C₁₄H₁₅FIN₃
• 分子量: 371.196
• InChiKey: BUNYVQYGAQAMLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-chloro-6-(1-fluoroethyl)-5-iodopyrimidine 、 2-苯乙胺 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 6-(1-fluoroethyl)-5-iodo-4-(2-phenylethylamino)pyrimidine
  参考文献：
  名称：

  5-Iodo-4-phenethylaminopyrimidine derivative, intermediate thereof, processes for producing the same and agricultural and horticultural pesticides

  摘要：

  本发明提供了一种新型的5-碘-4-苯乙基氨基嘧啶衍生物，其化学式表示如下（1）：其中R1代表卤素原子，C2-4酰氧基或羟基；R2代表氢原子，卤素原子，C1-4烷基，C1-4卤代烷基，C1-4烷氧基或C1-4卤代烷氧基；n为1至3的整数；*代表一个不对称碳原子，可用作杀虫剂，其合成中间体和生产这些化合物的过程，以及含有5-碘-4-苯乙基氨基嘧啶衍生物的杀虫剂。

  公开号：

  US06521627B1

文献信息

• 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use
  申请人：Sakai Masaaki

  公开号：US20120136150A1

  公开（公告）日：2012-05-31

  Novel 4-(3-butynyl)aminopyrimidine derivatives represented by general formula [I] are useful as pest control agents. In general formula [I], R 1 is a mono- or bi-cyclic ring which may contain 0 to 3 heteroatoms, for example, phenyl or oxazolyl; R 2 is a hydrogen atom, —R, —OR, —C(O)OR, —C(O)NHR, —CONR 2 (wherein R is straight-chain or branched C 1-8 alkyl, or the like), hydroxyalkyl, or the like; R 3 is a hydrogen atom, a halogen atom, acyloxy represented by (straight-chain or branched C 1-8 aliphatic hydrocarbon group) —CO—O—, or the like; and R 4 is a hydrogen atom, a halogen atom, C 1-6 alkyl, or the like, or alternatively, R 4 and R 3 together with the carbon atoms on the pyrimidine ring may form a thiophene ring, a pyrrole ring, an imidazole ring, a benzene ring, a pyrimidine ring, a furan ring, a pyrazine ring, or a pyrrolidine ring.

  通式[I]所表示的新型4-(3-丁炔基)氨基嘧啶衍生物可用作杀虫剂。在通式[I]中，R1是一个单环或双环环，可能含有0至3个杂原子，例如苯基或噁唑基；R2是氢原子，-R，-OR，-C（O）OR，-C（O）NHR，-CONR2（其中R是直链或支链C1-8烷基等），羟基烷基或类似物；R3是氢原子，卤素原子，酰氧基（由（直链或支链C1-8脂肪烃基）-CO-O-等表示），或类似物；R4是氢原子，卤素原子，C1-6烷基或类似物，或者，R4和R3与嘧啶环上的碳原子一起形成噻吩环，吡咯环，咪唑环，苯环，嘧啶环，呋喃环，吡嗪环或吡咯烷环。
• 5-IODO-4-PHENETHYLAMINOPYRIMIDINE DERIVATIVES, INTERMEDIATES THEREOF, PROCESS FOR PRODUCING THE SAME AND AGRICULTURAL/HORTICULTURAL PESTICIDES
  申请人：Ube Industries, Ltd.

  公开号：EP1074546A1

  公开（公告）日：2001-02-07

  The present invention is to provide a novel 5-iodo-4-phenethylaminopyrimidine derivative represented by the following formula (1): wherein R1 represents a halogen atom, a C2-4 acyloxy group or a hydroxyl group; R2 represents a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C1-4 haloalkyl group, a C1-4 alkoxy group or a C1-4 haloalkoxy group; n is an integer of 1 to 3; and * represents an asymmetric carbon atom, useful as pesticides, a synthetic intermediate thereof and processes for producing these compounds, and pesticides containing the 5-iodo-4-phenethylaminopyrimidine derivative(s).

  本发明旨在提供下式（1）所代表的新型 5-碘-4-苯乙胺嘧啶衍生物： 其中 R1 代表卤原子、C2-4 乙酰氧基或羟基；R2 代表氢原子、卤原子、C1-4 烷基、C1-4 卤烷基、C1-4 烷氧基或 C1-4 卤烷氧基；n 为 1 至 3 的整数；* 代表不对称碳原子、 可用作杀虫剂、其合成中间体和生产这些化合物的工艺，以及含有 5-碘-4-苯乙基氨基嘧啶衍生物的杀虫剂。
• 4-(3-BUTYNYL)AMINOPYRIMIDINE DERIVATIVES AS PEST CONTROL AGENTS FOR AGRICULTURAL AND HORTICULTURAL USE
  申请人：SDS Biotech K. K.

  公开号：EP2455371A1

  公开（公告）日：2012-05-23

  Novel 4-(3-butynyl)aminopyrimidine derivatives represented by general formula [I] are useful as pest control agents. In general formula [I], R1 is a mono- or bi-cyclic ring which may contain 0 to 3 heteroatoms, for example, phenyl or oxazolyl; R2 is a hydrogen atom, -R, -OR, -C(O)OR, -C(O)NHR, -CONR2 (wherein R is straight-chain or branched C1-8 alkyl, or the like), hydroxyalkyl, or the like; R3 is a hydrogen atom, a halogen atom, acyloxy represented by (straight-chain or branched C1-8 aliphatic hydrocarbon group) -CO-O-, or the like; and R4 is a hydrogen atom, a halogen atom, C1-6 alkyl, or the like, or alternatively, R4 and R3 together with the carbon atoms on the pyrimidine ring may form a thiophene ring, a pyrrole ring, an imidazole ring, a benzene ring, a pyrimidine ring, a furan ring, a pyrazine ring, or a pyrrolidine ring.

  通式[I]代表的新型 4-(3-丁炔基)氨基嘧啶衍生物可用作害虫防治剂。通式[I]中，R1 是单环或双环，可含有 0 至 3 个杂原子，例如苯基或噁唑基；R2 是氢原子、-R、-OR、-C(O)OR、-C(O)NHR、-CONR2（其中 R 是直链或支链 C1-8 烷基或类似物）、羟基烷基或类似物；R3 是氢原子、卤素原子、由（直链或支链 C1-8 脂肪族烃基）-CO-O- 代表的酰氧基或类似物；R4 是氢原子、卤素原子、C1-6 烷基或类似物，或者，R4 和 R3 与嘧啶环上的碳原子一起可形成噻吩环、吡咯环、咪唑环、苯环、嘧啶环、呋喃环、吡嗪环或吡咯烷环。
• JPH11302261A
  申请人：——

  公开号：JPH11302261A

  公开（公告）日：1999-11-02
• US6521627B1
  申请人：——

  公开号：US6521627B1

  公开（公告）日：2003-02-18