6-{2-chloro-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole | 848848-10-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-{2-chloro-4-[3-(4-methyl-piperazin-1-yl)-propoxy]-phenyl}-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole
• 英文别名: 6-[2-chloro-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]-5H-[1,3]dioxolo[4,5-f]benzimidazole
• CAS: 848848-10-2
• 化学式: C₂₂H₂₅ClN₄O₃
• 分子量: 428.918
• InChiKey: WWIVPRUACCPFGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Benzoimidazole compounds
  申请人：Arienti L. Kristen

  公开号：US20050070550A1

  公开（公告）日：2005-03-31

  Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 receptor-mediated conditions, and related conditions.

  苯并咪唑化合物、配方及其在白细胞召集抑制、调节H4受体以及治疗炎症、H4受体介导的疾病和相关疾病中的应用方法。
• Method for Pain Treatment
  申请人：Cowart Marlon D.

  公开号：US20080194538A1

  公开（公告）日：2008-08-14

  This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.

  这项发明揭示了一种通过给予组织胺H4受体配体和包含相同的组合物来治疗疼痛的方法。
• Benzoimidazole Compounds
  申请人：Edwards James P.

  公开号：US20090247508A1

  公开（公告）日：2009-10-01

  Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 receptor-mediated conditions, and related conditions.

  苯并咪唑化合物，组合物，以及它们在白细胞招募抑制，调节H4受体和治疗炎症，H4受体介导的疾病和相关疾病方面的使用方法。
• BENZOIMIDAZOLE COMPOUNDS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1673348A2

  公开（公告）日：2006-06-28
• Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus
  申请人：Dunford Paul J.

  公开号：US20090069343A1

  公开（公告）日：2009-03-12

  Patients suffering from pruritus or itch may be effectively treated by administering a centrally acting histamine H1 receptor antagonist (e.g., diphenhydramine, triprolidine, hydroxyzine, pyrilamine, promethazine, or chlorpheniramine) and a histamine H4 receptor antagonist (e.g., 5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone).