4-amino-7-chloro-5-(o-chlorophenyl)-<1,2,4>triazolo<1,5-a>quinoline-2-carboxylic acid | 104594-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-7-chloro-5-(o-chlorophenyl)-<1,2,4>triazolo<1,5-a>quinoline-2-carboxylic acid
• 英文别名: 4-amino-7-chloro-5-(2-chlorophenyl)-[1,2,4]triazolo[1,5-a]quinoline-2-carboxylic acid
• CAS: 104594-47-0
• 化学式: C₁₇H₁₀Cl₂N₄O₂
• 分子量: 373.198
• InChiKey: AXUUILVPBNSFMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-amino-7-chloro-5-(o-chlorophenyl)-<1,2,4>triazolo<1,5-a>quinoline-2-carboxylic acid 在 高氯酸 作用下， 以 乙醇 、 氯仿 、 乙腈 为溶剂， 生成 4-Amino-7-chloro-5-(2-chloro-phenyl)-[1,2,4]triazolo[1,5-a]quinoline-2-carboxylic acid; compound with perchloric acid
  参考文献：
  名称：

  Analytical studies on 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole hydrochloride dihydrate. II. A fluorometric method applicable to animal feed.

  摘要：

  A fluorometric method for the determination o 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1, 2, 4-triazole hydrochloride dihydrate (1) was established. This highly sensitive method was applied to the analysis of animal feed spiked with the drug. Compound 1 was easily transformed into the fluorophore 4-amino-7-chloro-5-(o-chlorophenyl)-[1, 2, 4]triazolo[1, 5-a]quinoline-2-carboxylic acid (2) in alkaline solution. After the extraction of 1 from the feed, 1 was converted into 2. The strong fluorescence of 2 allowed the establishment of a method with a quantitation limit of 5 mg/kg.Compound 1 in feed samples spiked at 10-500mg/kg was determined with a coefficient of variation of less than 10%. The concentration of 1, its uniformity in the whole feed and its stability can be evaluated by this method.

  DOI：

  10.1248/cpb.34.2873
• 作为产物：
  描述：

  1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole hydrochloride dihydrate 在 四丁基氢氧化铵 作用下， 反应 1.5h， 生成 4-amino-7-chloro-5-(o-chlorophenyl)-<1,2,4>triazolo<1,5-a>quinoline-2-carboxylic acid
  参考文献：
  名称：

  Analytical studies on 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1,2,4-triazole hydrochloride dihydrate. II. A fluorometric method applicable to animal feed.

  摘要：

  A fluorometric method for the determination o 1-(2-o-chlorobenzoyl-4-chlorophenyl)-5-glycylaminomethyl-3-dimethylaminocarbonyl-1H-1, 2, 4-triazole hydrochloride dihydrate (1) was established. This highly sensitive method was applied to the analysis of animal feed spiked with the drug. Compound 1 was easily transformed into the fluorophore 4-amino-7-chloro-5-(o-chlorophenyl)-[1, 2, 4]triazolo[1, 5-a]quinoline-2-carboxylic acid (2) in alkaline solution. After the extraction of 1 from the feed, 1 was converted into 2. The strong fluorescence of 2 allowed the establishment of a method with a quantitation limit of 5 mg/kg.Compound 1 in feed samples spiked at 10-500mg/kg was determined with a coefficient of variation of less than 10%. The concentration of 1, its uniformity in the whole feed and its stability can be evaluated by this method.

  DOI：

  10.1248/cpb.34.2873