6-but-3-enyl-2-[2-(trifluoromethyl)phenyl]-3H-pyrimidin-4-one | 656813-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-but-3-enyl-2-[2-(trifluoromethyl)phenyl]-3H-pyrimidin-4-one
• 英文别名: 4-but-3-enyl-2-[2-(trifluoromethyl)phenyl]-1H-pyrimidin-6-one
• CAS: 656813-95-5
• 化学式: C₁₅H₁₃F₃N₂O
• 分子量: 294.276
• InChiKey: ATLAZBHOBKNGAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3<br/>[FR] COMPOSITIONS PYRAZOLE CONVENANT COMME INHIBITEURS DE GSK-3
  申请人：VERTEX PHARMA

  公开号：WO2004013140A1

  公开（公告）日：2004-02-12

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供了式（I）的化合物或其药学上可接受的衍生物。这些化合物是蛋白激酶的抑制剂，特别是GSK3哺乳动物蛋白激酶的抑制剂。该发明还提供了包括本发明化合物的药学上可接受的组合物，以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• Compositions useful as inhibitors of GSK-3
  申请人：——

  公开号：US20040039007A1

  公开（公告）日：2004-02-26

  The present invention provides a compound of formula I: 1 or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供了化合物I的公式：1或其药学上可接受的衍生物。这些化合物是蛋白激酶的抑制剂，特别是哺乳动物GSK3蛋白激酶的抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3
  申请人：Forster Cornelia J.

  公开号：US20090118278A1

  公开（公告）日：2009-05-07

  The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供了I式化合物，或其药学上可接受的衍生物。这些化合物是蛋白激酶的抑制剂，特别是GSK3哺乳动物蛋白激酶的抑制剂。本发明还提供了包含本发明中化合物的药学上可接受的组合物，以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• Pyrazole compositions useful as inhibitors of gsk-3
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1739087A1

  公开（公告）日：2007-01-03

  The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供了一种式 I 的化合物： 或其药学上可接受的衍生物。这些化合物是蛋白激酶的抑制剂，特别是 GSK3 哺乳动物蛋白激酶的抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• PYRAZOLE COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP1532145A1

  公开（公告）日：2005-05-25