{4-[(6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-piperidin-1-yl}-piperazin-1-yl-methanone | 539828-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: {4-[(6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propyl-amino]-piperidin-1-yl}-piperazin-1-yl-methanone
• 英文别名: [4-[(6,7-Dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-propylamino]piperidin-1-yl]-piperazin-1-ylmethanone
• CAS: 539828-70-1
• 化学式: C₂₅H₄₀N₄O₃
• 分子量: 444.618
• InChiKey: QAHIMRFXRHCIOG-UHFFFAOYSA-N

物化性质

• 沸点：
  585.5±50.0 °C(Predicted)
• 密度：
  1.17±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  57.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• AMINO-TETRALIN DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：——

  公开号：US20030171362A1

  公开（公告）日：2003-09-11

  This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1 wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.

  本发明涉及一般为毒蕈碱M2/M3受体拮抗剂的化合物，其由式I所代表：其中R1、R2、R3和R4如规范中所定义，或其单体异构体、消旋或非消旋异构体混合物，或其可接受的盐或溶剂合物。该发明还涉及含有这种化合物的药物组合物以及用于其使用和制备作为治疗药物的方法。
• Amino-tetralin derivatives as muscarinic receptor antagonists
  申请人：——

  公开号：US20040092604A1

  公开（公告）日：2004-05-13

  This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: 1 wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.

  本发明涉及一般为肌肉型M2/M3受体拮抗剂的化合物，其由式I所表示：其中R1、R2、R3和R4如规范中所定义，或其个别异构体、外消旋或非外消旋异构体混合物，或其可接受的盐或溶剂化物。本发明进一步涉及含有这种化合物的制药组合物以及将其用作治疗药物的方法和制备方法。
• Resin composition for sealing semiconductors
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0397395A2

  公开（公告）日：1990-11-14

  A resin composition for sealing semiconductors which exhibits high heat resistance and is suitable for sealing semiconductor devices, etc., and which comprises an organic component containing a polymaleimide compound represented by the general formula : where R₁ is a m-valent organic group having at least 2 carbon atoms and m is a positive integer of 2 or more, and phenols mainly consisting of a phenol compound represented by the general formula : where n is a positive integer of 3 - 16, or an organic component containing (c) epoxy resin in addition to the polymaleimide and the phenol compound, and an inorganic filler.

  一种用于密封半导体的树脂组合物，该组合物具有高耐热性，适用于密封半导体器件等，它包括一种有机成分，其中含有一种由通式......表示的聚马来酰亚胺化合物： 其中，R₁ 是至少有 2 个碳原子的 m 价有机基团，m 是 2 个或 2 个以上的正整数；酚类主要包括通式如下的苯酚化合物 其中 n 为 3 - 16 的正整数，或一种有机成分，除聚马来酰亚胺和苯酚化合物外，还含有 (c) 环氧树脂和一种无机填料。
• Polyarylene sulfide resin composition
  申请人：Tonen Chemical Corporation

  公开号：EP1114847A1

  公开（公告）日：2001-07-11

  A resin composition is provided which composition comprises 100 parts by weight of (A)polyarylene sulfide, and 0.01 to 5.0 parts by weight of (B) a product compound of an element selected from the group consisting of group IIA and group IIB of the periodic table, wherein said product compound has such alkalinity that a mixture of said product compound with a 20-fold weight of ultrapure water of grade A4 specified in the Japanese Industrial Standards (JIS) K0557 has a pH of from 10.0 to 12.0. The composition is particularly suited to be used for an optical instrument part such as an object lens driving unit and the like.

  提供了一种树脂组合物，该组合物由 100 重量份的(A)聚芳基硫醚和 0.01 至 5.0 重量份的(B)一种选自元素周期表 IIA 族和 IIB 族的元素的产物化合物组成，其中所述产物化合物具有这样的碱性，即所述产物化合物与 20 倍重量的日本工业标准 (JIS) K0557 中规定的 A4 级超纯水的混合物的 pH 值为 10.0 至 12.0。该组合物特别适合用于光学仪器部件，如物镜驱动单元等。
• Part of an object lens driving unit made from a polyarylene sulfide resin composition
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1114847B1

  公开（公告）日：2004-11-17