4-(dodecyloxy)-2-fluorobenzoyl chloride | 1228114-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(dodecyloxy)-2-fluorobenzoyl chloride
• CAS: 1228114-94-0
• 化学式: C₁₉H₂₈ClFO₂
• 分子量: 342.882
• InChiKey: MVCPNIKHEZERKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  23.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-(dodecyloxy)-2-fluorobenzoyl chloride 、 4-(dodecyloxy)benzohydrazide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以0.9 g的产率得到N'-(4-(dodecyloxy)benzoyl)-N-(4-(dodecyloxy)-2-fluorobenzoyl)hydrazine
  参考文献：
  名称：

  Liquid Crystals Derived from Semifluorinated Alkoxybenzoyl Hydrazines

  摘要：

  A variety of liquid crystals with semifluorinated tails including 4-alkoxybenzoic acids (1d-h), 4-alkoxybenzoyl hydrazines (2d-h), and N,N'-bis(4-alkoxybenzoyl) hydrazines (3d-m) have been synthesized, and their properties are compared with their perhydrogenated analogs. Semifluorination in compounds 1d-h suppressed nematic phases, and semifluorinated compounds 2d-h exhibit mesogenic behavior where none is found in their perhydrogenated counterparts. Compounds 3a-c with perhydrogenated chains display Cub and SmC phases. Introduction of one semifluorinated chain, 3d-h suppresses the Cub phase but induces a SmA phase, with lower melting but higher clearing temperatures compared to compounds with two semifluorinated chains, 3i-m. The mesogenic properties of some selected binary mixtures of these compounds 3a-d and some lateral fluoro substituted N,N'-bis (4-alkoxybenzoyl) hydrazines 7-9 are also discussed.

  DOI：

  10.1080/15421400902841478
• 作为产物：
  描述：

  2-fluoro-4-(n-dodecyloxy)benzonitrile 在 草酰氯 、 硫酸 、 水 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 80.0h， 生成 4-(dodecyloxy)-2-fluorobenzoyl chloride
  参考文献：
  名称：

  Liquid Crystals Derived from Semifluorinated Alkoxybenzoyl Hydrazines

  摘要：

  A variety of liquid crystals with semifluorinated tails including 4-alkoxybenzoic acids (1d-h), 4-alkoxybenzoyl hydrazines (2d-h), and N,N'-bis(4-alkoxybenzoyl) hydrazines (3d-m) have been synthesized, and their properties are compared with their perhydrogenated analogs. Semifluorination in compounds 1d-h suppressed nematic phases, and semifluorinated compounds 2d-h exhibit mesogenic behavior where none is found in their perhydrogenated counterparts. Compounds 3a-c with perhydrogenated chains display Cub and SmC phases. Introduction of one semifluorinated chain, 3d-h suppresses the Cub phase but induces a SmA phase, with lower melting but higher clearing temperatures compared to compounds with two semifluorinated chains, 3i-m. The mesogenic properties of some selected binary mixtures of these compounds 3a-d and some lateral fluoro substituted N,N'-bis (4-alkoxybenzoyl) hydrazines 7-9 are also discussed.

  DOI：

  10.1080/15421400902841478

文献信息

• Diphenyl-1,3,4-oxadiazoles: synthesis and influence of side chain semifluorination and lateral ring fluorination on liquid crystalline properties
  作者：Farid S. Fouad、Melati Khairuddean、Robert J. Twieg

  DOI：10.1080/15421406.2021.1980711

  日期：2022.1.2

  Abstract We present the synthesis and liquid crystalline properties of four sets of diphenyl-1,3,4-oxadiazole based compounds (Sets 1–4). The influence of side chain and lateral fluorinations is discussed. In this study, side chain fluorination (Sets 2 and 3) induces liquid crystalline properties, while lateral fluorination (Set 4) has not induced mesogenic properties. Compounds with either one or

  摘要 我们介绍了四组基于二苯基-1,3,4-恶二唑的化合物（第 1-4 组）的合成和液晶性质。讨论了侧链和侧向氟化的影响。在本研究中，侧链氟化（第 2 组和第 3 组）诱导液晶性质，而侧链氟化（第 4 组）没有诱导介晶性质。具有一个或两个半氟化侧链的化合物是近晶介晶（SmC 和/或 SmA）。二苯基-1,3,4-恶二唑、联苯基-1,3,4-恶二唑、二苯基-1,3,4-噻二唑和联苯基-1,2,4-恶二唑核之间的比较，我们有以前报道过，讨论过。