2-[1-(2,2-diphenylethyl)piperidin-4-yl]oxy-N-[2-(2-fluorophenyl)-2-pyrrolidin-1-ylethyl]benzamide | 947511-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-(2,2-diphenylethyl)piperidin-4-yl]oxy-N-[2-(2-fluorophenyl)-2-pyrrolidin-1-ylethyl]benzamide
• CAS: 947511-07-1
• 化学式: C₃₈H₄₂FN₃O₂
• 分子量: 591.769
• InChiKey: IWTXFQRLQZTJCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Hydroxypiperidine Derivatives and Uses Thereof
  申请人：Ohler Norman E.

  公开号：US20090036429A1

  公开（公告）日：2009-02-05

  Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
• Hydroxypiperidine derivatives and uses thereof
  申请人：Ohler Norman E.

  公开号：US20110178066A1

  公开（公告）日：2011-07-21

  Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.