2-(4-bromobutoxy)diphenylmethylmethane | 343229-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-bromobutoxy)diphenylmethylmethane
• 英文别名: 1-(4-Bromobutoxy)-2-(1-phenylethyl)benzene
• CAS: 343229-59-4
• 化学式: C₁₈H₂₁BrO
• 分子量: 333.268
• InChiKey: CCHFYTHEGHLRSV-UHFFFAOYSA-N

物化性质

• 沸点：
  424.5±38.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-bromobutoxy)diphenylmethylmethane 、 甲胺 以 乙醇 、 水 为溶剂， 反应 24.0h， 生成 2-(4-Methylamino-butoxy)-diphenylmethylmethan
  参考文献：
  名称：

  Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives

  摘要：

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

  DOI：

  10.1021/jm00134a004
• 作为产物：
  描述：

  1,4-二溴丁烷 、 (1-苯基乙基)-苯酚 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成 2-(4-bromobutoxy)diphenylmethylmethane
  参考文献：
  名称：

  Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives

  摘要：

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

  DOI：

  10.1021/jm00134a004

文献信息

• KIKUMOTO RYOJI; TOBE AKIHIRO; TONOMURA SHINJI, J. MED. CHEM., 1981, 24, NO 2, 145-148
  作者：KIKUMOTO RYOJI、 TOBE AKIHIRO、 TONOMURA SHINJI

  DOI：——

  日期：——
• US4100299A
  申请人：——

  公开号：US4100299A

  公开（公告）日：1978-07-11
• Synthesis and antidepressant activity of substituted (.omega.-aminoalkoxy)benzene derivatives
  作者：Ryoji Kikumoto、Akihiro Tobe、Shinji Tonomura

  DOI：10.1021/jm00134a004

  日期：1981.2

  A series of substituted (omega-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4-(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.