3-(4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)piperidin-1yl)propanenitrile | 1415151-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)piperidin-1yl)propanenitrile
• 英文别名: 3-[4-[[5-Amino-2-[(2-methoxypyridin-3-yl)amino]pyrimidin-4-yl]amino]piperidin-1-yl]propanenitrile
• CAS: 1415151-80-2
• 化学式: C₁₈H₂₄N₈O
• 分子量: 368.442
• InChiKey: GQASXHKFXSGOAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES<br/>[FR] DÉRIVÉS DE PYRIDIN-2(1H)-ONE UTILES EN TANT QUE MÉDICAMENTS POUR LE TRAITEMENT DE TROUBLES MYÉLOPROLIFÉRATIFS, DU REJET DE GREFFE, DE MALADIES À MÉDIATION IMMUNITAIRE ET INFLAMMATOIRES
  申请人：ALMIRALL SA

  公开号：WO2012160030A1

  公开（公告）日：2012-11-29

  Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  揭示了具有化学结构的化合物（I）的公式；以及它们的制备过程，包括它们的药物组合物和它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• PYRIDIN-2(1H)-ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES
  申请人：Eastwood Paul Robert

  公开号：US20140170110A1

  公开（公告）日：2014-06-19

  Compounds having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  公开了具有化学式（I）的化合物；以及它们的制备方法、包含它们的制药组合物以及它们作为Janus激酶（JAK）抑制剂在治疗中的用途。